Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1987 Nov;42(11):881–884. doi: 10.1136/thx.42.11.881

Effect of high dose inhaled beclomethasone dipropionate on carbohydrate and lipid metabolism in normal subjects.

Y T Kruszynska 1, M Greenstone 1, P D Home 1, N J Cooke 1
PMCID: PMC461014  PMID: 3321544

Abstract

The metabolic effects of four weeks' high dose inhaled beclomethasone dipropionate (500 micrograms twice daily) were studied in nine normal subjects with an open study design. No effect was found on fasting blood glucose concentration or glycosylated haemoglobin concentration. Peak blood glucose concentration 30 minutes after a 75 g oral glucose load was, however, significantly higher (7.1 (SEM 0.2) versus 6.7 (0.1) mmol/l, or 128 (3.6) v 121 (1.8) mg/100 ml). After treatment there was a 36% increase in fasting serum insulin concentration (7.6 (0.7) versus 5.6 (0.5) mU/l) and a 32% increase in the area under the serum insulin concentration curve after glucose challenge. High dose inhaled beclomethasone dipropionate treatment raised the fasting plasma cholesterol concentration (4.62 (0.25) v 4.16 (0.26) mmol/l, or 178 (9.7) v 161 (10.0) mg/100 ml) and high density lipoprotein cholesterol (1.19 (0.065) versus 0.97 (0.065) mmol/l, or 45 (2.5) v 37 (2.5) mg/100 ml). Fasting blood lactate and pyruvate concentrations were also significantly higher and blood glycerol lower. The findings indicate that high dose inhaled beclomethasone dipropionate may disturb both carbohydrate and lipid metabolism.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baum C. K., Tudor R., Landon J. A simple competitive protein binding assay for plasma cortisol. Clin Chim Acta. 1974 Sep 16;55(2):147–154. doi: 10.1016/0009-8981(74)90291-5. [DOI] [PubMed] [Google Scholar]
  2. Doar J. W., Wynn V. Effects of obesity, glucocorticoid, and oral contraceptive therapy on plasma glucose and blood pyruvate levels. Br Med J. 1970 Jan 17;1(5689):149–152. doi: 10.1136/bmj.1.5689.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gaddie J., Petrie G. R., Reid I. W., Skinner C., Sinclair D. J., Palmer K. N. Aerosol beclomethasone dipropionate: a dose-response study in chronic bronchial asthma. Lancet. 1973 Aug 11;2(7824):280–281. doi: 10.1016/s0140-6736(73)90788-5. [DOI] [PubMed] [Google Scholar]
  4. Gelehrter T. D. Syneristic and antagonistic effects of glucocorticoids on insulin action. Monogr Endocrinol. 1979;12:583–591. doi: 10.1007/978-3-642-81265-1_32. [DOI] [PubMed] [Google Scholar]
  5. Goldstein D. E., König P. Effect of inhaled beclomethasone dipropionate on hypothalamic-pituitary-adrenal axis function in children with asthma. Pediatrics. 1983 Jul;72(1):60–64. [PubMed] [Google Scholar]
  6. Ingebritsen T. S., Geelen M. J., Parker R. A., Evenson K. J., Gibson D. M. Modulation of hydroxymethylglutaryl-CoA reductase activity, reductase kinase activity, and cholesterol synthesis in rat hepatocytes in response to insulin and glucagon. J Biol Chem. 1979 Oct 25;254(20):9986–9989. [PubMed] [Google Scholar]
  7. Johnston D. G., Alberti K. G., Binder C., Faber O. K., Wright R., Orskov H. Hormonal and metabolic changes in hepatic cirrhosis. Horm Metab Res. 1982 Jan;14(1):34–39. doi: 10.1055/s-2007-1018914. [DOI] [PubMed] [Google Scholar]
  8. Johnston D. G., Alberti K. G., Nattrass M., Barnes A. J., Bloom S. R., Joplin G. F. Hormonal and metabolic rhythms in Cushing's syndrome. Metabolism. 1980 Oct;29(11):1046–1052. doi: 10.1016/0026-0495(80)90215-2. [DOI] [PubMed] [Google Scholar]
  9. Lloyd B., Burrin J., Smythe P., Alberti K. G. Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin Chem. 1978 Oct;24(10):1724–1729. [PubMed] [Google Scholar]
  10. Rose G., Shipley M. Plasma cholesterol concentration and death from coronary heart disease: 10 year results of the Whitehall study. Br Med J (Clin Res Ed) 1986 Aug 2;293(6542):306–307. doi: 10.1136/bmj.293.6542.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Smith M. J., Hodson M. E. Effects of long term inhaled high dose beclomethasone dipropionate on adrenal function. Thorax. 1983 Sep;38(9):676–681. doi: 10.1136/thx.38.9.676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stickland M. H., Perkins C. M., Wales J. K. The Measurement of Haemoglobin A1c by isoelectric focussing in diabetic patients. Diabetologia. 1982 May;22(5):315–317. doi: 10.1007/BF00253573. [DOI] [PubMed] [Google Scholar]
  13. Stout R. W. Diabetes and atherosclerosis--the role of insulin. Diabetologia. 1979 Mar;16(3):141–150. doi: 10.1007/BF01219790. [DOI] [PubMed] [Google Scholar]
  14. Warnick G. R., Albers J. J. A comprehensive evaluation of the heparin-manganese precipitation procedure for estimating high density lipoprotein cholesterol. J Lipid Res. 1978 Jan;19(1):65–76. [PubMed] [Google Scholar]
  15. Yernault J. C., Leclercq R., Schandevyl W., Virasoro E., De Coster A., Copinschi G. The endocrinometabolic effects of beclomethasone dipropionate in asthmatic patients. Chest. 1977 Jun;71(6):698–702. doi: 10.1378/chest.71.6.698. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES