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. 1988 Mar;43(3):175–182. doi: 10.1136/thx.43.3.175

Rate of increase in pulmonary distensibility in a longitudinal study of smokers.

H J Colebatch 1, C K Ng 1
PMCID: PMC461157  PMID: 3406901

Abstract

To examine the hypothesis that an abnormally rapid increase in pulmonary distensibility occurs in cigarette smokers, 39 adult smokers (24 men), mean age 47 (SD 8) years, who were not disabled were studied on two occasions over a mean interval of 3.5 (SD 0.5) years. Exponential analysis of static pressure-volume data obtained during deflation of the lungs gave the exponent K, an index of distensibility. Total lung capacity (TLC) was measured in a body plethysmograph. At entry into the longitudinal study means values for K and static recoil pressure in the 39 smokers available for follow up were similar to those obtained in the original group of 101 smokers (73 men), mean age 42 (SD 11) years, in the cross sectional study. Over the interval of the study, ln K and TLC increased and FEV1 decreased at rates greater than those found in a previous longitudinal study of 34 non-smokers (24 men), mean age 42 (SD 15) years. In the longitudinal study of smokers the observed changes in K and in recoil pressure over the interval of study were greater than the values obtained from the regression slopes found in the cross sectional study of smokers. On the basis of the regression model used previously in the longitudinal study of non-smokers, the age coefficient for ln K was greater than that found in the non-smokers (p less than 0.01). The regression model also showed that the slope of ln K on age increased in older subjects. Because K is related to peripheral airspace size, a rapid rate of increase in K identifies smokers in whom airspace size is increasing abnormally rapidly. In this study the rate of increase in K and the variation between subjects was sufficient to explain the magnitude of the increased pulmonary distensibility found in cigarette smokers who present with emphysema.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berend N., Skoog C., Thurlbeck W. M. Pressure-volume characteristics of excised human lungs: effects of sex, age, and emphysema. J Appl Physiol Respir Environ Exerc Physiol. 1980 Oct;49(4):558–565. doi: 10.1152/jappl.1980.49.4.558. [DOI] [PubMed] [Google Scholar]
  2. Colebatch H. J., Greaves I. A. Chronic airflow obstruction. Evolution of disordered function in cigarette smokers. Med J Aust. 1985 May 27;142(11):607–610. [PubMed] [Google Scholar]
  3. Colebatch H. J., Greaves I. A., Ng C. K. Exponential analysis of elastic recoil and aging in healthy males and females. J Appl Physiol Respir Environ Exerc Physiol. 1979 Oct;47(4):683–691. doi: 10.1152/jappl.1979.47.4.683. [DOI] [PubMed] [Google Scholar]
  4. Colebatch H. J., Greaves I. A., Ng C. K. Pulmonary distensibility and ventilatory function in smokers. Bull Eur Physiopathol Respir. 1985 Sep-Oct;21(5):439–447. [PubMed] [Google Scholar]
  5. Colebatch H. J., Nail B. S., Ng C. K. Computerized measurement of pulmonary conductance and elastic recoil. J Appl Physiol Respir Environ Exerc Physiol. 1978 Apr;44(4):611–618. doi: 10.1152/jappl.1978.44.4.611. [DOI] [PubMed] [Google Scholar]
  6. Colebatch H. J., Ng C. K. A longitudinal study of pulmonary distensibility in healthy adults. Respir Physiol. 1986 Jul;65(1):1–11. doi: 10.1016/0034-5687(86)90002-2. [DOI] [PubMed] [Google Scholar]
  7. Colebatch H. J., Ng C. K., Nikov N. Use of an exponential function for elastic recoil. J Appl Physiol Respir Environ Exerc Physiol. 1979 Feb;46(2):387–393. doi: 10.1152/jappl.1979.46.2.387. [DOI] [PubMed] [Google Scholar]
  8. Corbin R. P., Loveland M., Martin R. R., Macklem P. T. A four-year follow-up study of lung mechanics in smokers. Am Rev Respir Dis. 1979 Aug;120(2):293–304. doi: 10.1164/arrd.1979.120.2.293. [DOI] [PubMed] [Google Scholar]
  9. Fletcher C., Peto R. The natural history of chronic airflow obstruction. Br Med J. 1977 Jun 25;1(6077):1645–1648. doi: 10.1136/bmj.1.6077.1645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gadek J. E., Fells G. A., Zimmerman R. L., Rennard S. I., Crystal R. G. Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema. J Clin Invest. 1981 Oct;68(4):889–898. doi: 10.1172/JCI110344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gadek J. E., Hunninghake G. W., Fells G. A., Zimmerman R. L., Keogh B. A., Crystal R. G. Evaluation of the protease-antiprotease theory of human destructive lung disease. Bull Eur Physiopathol Respir. 1980;16 (Suppl):27–40. doi: 10.1016/b978-0-08-027379-2.50005-3. [DOI] [PubMed] [Google Scholar]
  12. Greaves I. A., Colebatch H. J. Elastic behavior and structure of normal and emphysematous lungs post mortem. Am Rev Respir Dis. 1980 Jan;121(1):127–136. doi: 10.1164/arrd.1980.121.1.127. [DOI] [PubMed] [Google Scholar]
  13. Greaves I. A., Colebatch H. J. Observations on the pathogenesis of chronic airflow obstruction in smokers: implications for the detection of "early" lung disease. Thorax. 1986 Feb;41(2):81–87. doi: 10.1136/thx.41.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Haber P. S., Colebatch H. J., Ng C. K., Greaves I. A. Alveolar size as a determinant of pulmonary distensibility in mammalian lungs. J Appl Physiol Respir Environ Exerc Physiol. 1983 Mar;54(3):837–845. doi: 10.1152/jappl.1983.54.3.837. [DOI] [PubMed] [Google Scholar]
  15. Janoff A. Biochemical links between cigarette smoking and pulmonary emphysema. J Appl Physiol Respir Environ Exerc Physiol. 1983 Aug;55(2):285–293. doi: 10.1152/jappl.1983.55.2.285. [DOI] [PubMed] [Google Scholar]
  16. Kucich U., Christner P., Lippmann M., Kimbel P., Williams G., Rosenbloom J., Weinbaum G. Utilization of a peroxidase antiperoxidase complex in an enzyme-linked immunosorbent assay of elastin-derived peptides in human plasma. Am Rev Respir Dis. 1985 May;131(5):709–713. doi: 10.1164/arrd.1985.131.5.709. [DOI] [PubMed] [Google Scholar]
  17. Silvers G. W., Petty T. L., Stanford R. E. Elastic recoil changes in early emphysema. Thorax. 1980 Jul;35(7):490–495. doi: 10.1136/thx.35.7.490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop. Am Rev Respir Dis. 1985 Jul;132(1):182–185. doi: 10.1164/arrd.1985.132.1.182. [DOI] [PubMed] [Google Scholar]
  19. Thurlbeck W. M. Internal surface area and other measurements in emphysema. Thorax. 1967 Nov;22(6):483–496. doi: 10.1136/thx.22.6.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Thurlbeck W. M. Post-mortem lung volumes. Thorax. 1979 Dec;34(6):735–739. doi: 10.1136/thx.34.6.735. [DOI] [PMC free article] [PubMed] [Google Scholar]

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