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. 1988 Aug;43(8):627–630. doi: 10.1136/thx.43.8.627

Chickenpox pneumonia: experience with antiviral treatment.

R N Davidson 1, W Lynn 1, P Savage 1, M H Wansbrough-Jones 1
PMCID: PMC461399  PMID: 3175975

Abstract

Of 13 patients with chickenpox pneumonia (12 of them adults) treated during 1979-87, 10 received antiviral drugs--nine acyclovir and one vidarabine. Three died despite intensive treatment. Serious secondary infections occurred in six cases. There were no clear indications that antiviral treatment altered the natural history of the condition. Acyclovir may at present be used too late in the course of chickenpox pneumonia to alter its outcome.

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Selected References

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  1. Arvin A. M., Kushner J. H., Feldman S., Baehner R. L., Hammond D., Merigan T. C. Human leukocyte interferon for the treatment of varicella in children with cancer. N Engl J Med. 1982 Apr 1;306(13):761–765. doi: 10.1056/NEJM198204013061301. [DOI] [PubMed] [Google Scholar]
  2. BOCLES J. S., EHRENKRANZ N. J., MARKS A. ABNORMALITIES OF RESPIRATORY FUNCTION IN VARICELLA PNEUMONIA. Ann Intern Med. 1964 Feb;60:183–195. doi: 10.7326/0003-4819-60-2-183. [DOI] [PubMed] [Google Scholar]
  3. Balfour H. H., Jr Intravenous acyclovir therapy for varicella in immunocompromised children. J Pediatr. 1984 Jan;104(1):134–136. doi: 10.1016/s0022-3476(84)80611-3. [DOI] [PubMed] [Google Scholar]
  4. Brunell P. A. Varicella-zoster virus vaccine. JAMA. 1978 Mar 13;239(11):1034–1035. [PubMed] [Google Scholar]
  5. Bryer A., Potgieter P. D., Moodie J. Acyclovir and varicella pneumonia. S Afr Med J. 1984 Oct 6;66(14):515–515. [PubMed] [Google Scholar]
  6. Ellis M. E., Neal K. R., Webb A. K. Is smoking a risk factor for pneumonia in adults with chickenpox? Br Med J (Clin Res Ed) 1987 Apr 18;294(6578):1002–1002. doi: 10.1136/bmj.294.6578.1002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Foung S. K., Perkins S., Koropchak C., Fishwild D. M., Wittek A. E., Engleman E. G., Grumet F. C., Arvin A. M. Human monoclonal antibodies neutralizing varicella-zoster virus. J Infect Dis. 1985 Aug;152(2):280–285. doi: 10.1093/infdis/152.2.280. [DOI] [PubMed] [Google Scholar]
  8. Gershon A. A. Live attenuated varicella vaccine. J Infect Dis. 1985 Nov;152(5):859–862. doi: 10.1093/infdis/152.5.859. [DOI] [PubMed] [Google Scholar]
  9. Gershon A., Brunell P. A., Doyle E. F., Claps A. A. Steroid therapy and varicella. J Pediatr. 1972 Nov;81(5):1034–1034. doi: 10.1016/s0022-3476(72)80566-3. [DOI] [PubMed] [Google Scholar]
  10. HAMPTON A. G., Jr Primary varicella pneumonia. AMA Arch Intern Med. 1955 Jan;95(1):137–140. doi: 10.1001/archinte.1955.00250070153019. [DOI] [PubMed] [Google Scholar]
  11. Joseph C. A., Noah N. D. Epidemiology of chickenpox in England and Wales, 1967-85. Br Med J (Clin Res Ed) 1988 Mar 5;296(6623):673–676. doi: 10.1136/bmj.296.6623.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. KRUGMAN S., GOODRICH C. H., WARD R. Primary varicella pneumonia. N Engl J Med. 1957 Oct 31;257(18):843–848. doi: 10.1056/NEJM195710312571801. [DOI] [PubMed] [Google Scholar]
  13. Knyvett A. F. The pulmonary lesions of chickenpox. Q J Med. 1966 Jul;35(139):313–323. [PubMed] [Google Scholar]
  14. Lankford J., Orr E. R., Nitschke R., Humphrey G. B. A case of varicella pneumonia treated with transfer factor. JAMA. 1979 Jun 15;241(24):2598–2598. [PubMed] [Google Scholar]
  15. MERMELSTEIN R. H., FREIREICH A. W. Varicella pneumonia. Ann Intern Med. 1961 Sep;55:456–463. doi: 10.7326/0003-4819-55-3-456. [DOI] [PubMed] [Google Scholar]
  16. MONTGOMERY R. R., OLAFSSON M. Waterhouse-Friderichsen syndrome in varicella. Ann Intern Med. 1960 Sep;53:576–579. doi: 10.7326/0003-4819-53-3-576. [DOI] [PubMed] [Google Scholar]
  17. Macfarlane J. T., Smith F. D., Finch R. G. Vidarabine in fulminating chickenpox pneumonia. Thorax. 1982 Mar;37(3):226–227. doi: 10.1136/thx.37.3.226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Nisenbaum C., Wallis K., Herczeg E. Varicella pneumonia in children. Helv Paediatr Acta. 1969 Apr;24(2):212–218. [PubMed] [Google Scholar]
  19. Pillans P. Chickenpox pneumonia. A case report. S Afr Med J. 1983 May 28;63(22):861–862. [PubMed] [Google Scholar]
  20. ROSS A. H. Modification of chicken pox in family contacts by administration of gamma globulin. N Engl J Med. 1962 Aug 23;267:369–376. doi: 10.1056/NEJM196208232670801. [DOI] [PubMed] [Google Scholar]
  21. Rose R. M., Wasserman A. S., Weiser W. Y., Remold H. G. Deficient responses of pulmonary macrophages from healthy smokers to antiviral lymphokines in vitro. J Infect Dis. 1986 Oct;154(4):611–618. doi: 10.1093/infdis/154.4.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sabin A. B. Varicella-zoster virus vaccine. JAMA. 1977 Oct 17;238(16):1731–1733. [PubMed] [Google Scholar]
  23. Shulman S. T. Acyclovir treatment of disseminated varicella in childhood malignant neoplasms. Am J Dis Child. 1985 Feb;139(2):137–140. doi: 10.1001/archpedi.1985.02140040035021. [DOI] [PubMed] [Google Scholar]
  24. Takahashi M., Otsuka T., Okuno Y., Asano Y., Yazaki T. Live vaccine used to prevent the spread of varicella in children in hospital. Lancet. 1974 Nov 30;2(7892):1288–1290. doi: 10.1016/s0140-6736(74)90144-5. [DOI] [PubMed] [Google Scholar]
  25. Teare E. L., Cohen J. A. Treatment of chickenpox pneumonia with adenine arabinoside. Lancet. 1979 Apr 21;1(8121):873–873. doi: 10.1016/s0140-6736(79)91284-4. [DOI] [PubMed] [Google Scholar]
  26. Triebwasser J. H., Harris R. E., Bryant R. E., Rhoades E. R. Varicella pneumonia in adults. Report of seven cases and a review of literature. Medicine (Baltimore) 1967 Sep;46(5):409–423. [PubMed] [Google Scholar]
  27. WEBER D. M., PELLECCHIA J. A. VARICELLA PNEUMONIA: STUDY OF PREVALENCE IN ADULT MEN. JAMA. 1965 May 10;192:572–573. doi: 10.1001/jama.1965.03080190138035. [DOI] [PubMed] [Google Scholar]
  28. WEINSTEIN L., MEADE R. H. Respiratory manifestations of chicken pox; special consideration of the features of primary varicella pneumonia. AMA Arch Intern Med. 1956 Jul;98(1):91–99. doi: 10.1001/archinte.1956.00250250097013. [DOI] [PubMed] [Google Scholar]
  29. Winsnes R. Efficacy of zoster immunoglobulin in prophylaxis of varicella in high-risk patients. Acta Paediatr Scand. 1978 Jan;67(1):77–82. doi: 10.1111/j.1651-2227.1978.tb16280.x. [DOI] [PubMed] [Google Scholar]
  30. van der Meer J. W., Thompson J., Tan W. D., Versteeg J. Treatment of chickenpox pneumonia with acyclovir. Lancet. 1980 Aug 30;2(8192):473–474. doi: 10.1016/s0140-6736(80)91904-2. [DOI] [PubMed] [Google Scholar]

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