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. 1988 Sep;43(9):665–668. doi: 10.1136/thx.43.9.665

Epithelium derived relaxing factor: myth or reality?

P M Vanhoutte 1
PMCID: PMC461452  PMID: 3057676

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Advenier C., Devillier P., Matran R., Naline E. Influence of epithelium on the responsiveness of guinea-pig isolated trachea to adenosine. Br J Pharmacol. 1988 Feb;93(2):295–302. doi: 10.1111/j.1476-5381.1988.tb11434.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Agrawal D. K., Schugel J. W., Townley R. G. Comparison of beta adrenoceptors in bovine airway epithelium and smooth muscle cells. Biochem Biophys Res Commun. 1987 Oct 14;148(1):178–183. doi: 10.1016/0006-291x(87)91092-8. [DOI] [PubMed] [Google Scholar]
  3. Butler G. B., Adler K. B., Evans J. N., Morgan D. W., Szarek J. L. Modulation of rabbit airway smooth muscle responsiveness by respiratory epithelium. Involvement of an inhibitory metabolite of arachidonic acid. Am Rev Respir Dis. 1987 May;135(5):1099–1104. doi: 10.1164/arrd.1987.135.5.1099. [DOI] [PubMed] [Google Scholar]
  4. Carstairs J. R., Nimmo A. J., Barnes P. J. Autoradiographic localisation of beta-adrenoceptors in human lung. Eur J Pharmacol. 1984 Aug 3;103(1-2):189–190. doi: 10.1016/0014-2999(84)90211-5. [DOI] [PubMed] [Google Scholar]
  5. Carstairs J. R., Nimmo A. J., Barnes P. J. Autoradiographic visualization of beta-adrenoceptor subtypes in human lung. Am Rev Respir Dis. 1985 Sep;132(3):541–547. doi: 10.1164/arrd.1985.132.3.541. [DOI] [PubMed] [Google Scholar]
  6. Farmer S. G., Hay D. W., Raeburn D., Fedan J. S. Relaxation of guinea-pig tracheal smooth muscle to arachidonate is converted to contraction following epithelium removal. Br J Pharmacol. 1987 Sep;92(1):231–236. doi: 10.1111/j.1476-5381.1987.tb11316.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Flavahan N. A., Aarhus L. L., Rimele T. J., Vanhoutte P. M. Respiratory epithelium inhibits bronchial smooth muscle tone. J Appl Physiol (1985) 1985 Mar;58(3):834–838. doi: 10.1152/jappl.1985.58.3.834. [DOI] [PubMed] [Google Scholar]
  8. Furchgott R. F. The role of endothelium in the responses of vascular smooth muscle to drugs. Annu Rev Pharmacol Toxicol. 1984;24:175–197. doi: 10.1146/annurev.pa.24.040184.001135. [DOI] [PubMed] [Google Scholar]
  9. Furchgott R. F., Zawadzki J. V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980 Nov 27;288(5789):373–376. doi: 10.1038/288373a0. [DOI] [PubMed] [Google Scholar]
  10. Goldie R. G., Papadimitriou J. M., Paterson J. W., Rigby P. J., Self H. M., Spina D. Influence of the epithelium on responsiveness of guinea-pig isolated trachea to contractile and relaxant agonists. Br J Pharmacol. 1986 Jan;87(1):5–14. doi: 10.1111/j.1476-5381.1986.tb10150.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hay D. W., Farmer S. G., Raeburn D., Muccitelli R. M., Wilson K. A., Fedan J. S. Differential effects of epithelium removal on the responsiveness of guinea-pig tracheal smooth muscle to bronchoconstrictors. Br J Pharmacol. 1987 Oct;92(2):381–388. doi: 10.1111/j.1476-5381.1987.tb11334.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hay D. W., Farmer S. G., Raeburn D., Robinson V. A., Fleming W. W., Fedan J. S. Airway epithelium modulates the reactivity of guinea-pig respiratory smooth muscle. Eur J Pharmacol. 1986 Sep 23;129(1-2):11–18. doi: 10.1016/0014-2999(86)90330-4. [DOI] [PubMed] [Google Scholar]
  13. Hay D. W., Muccitelli R. M., Horstemeyer D. L., Wilson K. A., Raeburn D. Demonstration of the release of an epithelium-derived inhibitory factor from a novel preparation of guinea-pig trachea. Eur J Pharmacol. 1987 Apr 14;136(2):247–250. doi: 10.1016/0014-2999(87)90719-9. [DOI] [PubMed] [Google Scholar]
  14. Hay D. W., Raeburn D., Farmer S. G., Fleming W. W., Fedan J. S. Epithelium modulates the reactivity of ovalbumin-sensitized guinea-pig airway smooth muscle. Life Sci. 1986 Jun 30;38(26):2461–2468. doi: 10.1016/0024-3205(86)90617-x. [DOI] [PubMed] [Google Scholar]
  15. Holroyde M. C. The influence of epithelium on the responsiveness of guinea-pig isolated trachea. Br J Pharmacol. 1986 Mar;87(3):501–507. doi: 10.1111/j.1476-5381.1986.tb10192.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ilhan M., Sahin I. Tracheal epithelium releases a vascular smooth muscle relaxant factor: demonstration by bioassay. Eur J Pharmacol. 1986 Nov 19;131(2-3):293–296. doi: 10.1016/0014-2999(86)90586-8. [DOI] [PubMed] [Google Scholar]
  17. Laitinen L. A., Heino M., Laitinen A., Kava T., Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis. 1985 Apr;131(4):599–606. doi: 10.1164/arrd.1985.131.4.599. [DOI] [PubMed] [Google Scholar]
  18. Munakata M., Mitzner W., Menkes H. Osmotic stimuli induce epithelial-dependent relaxation in the guinea pig trachea. J Appl Physiol (1985) 1988 Jan;64(1):466–471. doi: 10.1152/jappl.1988.64.1.466. [DOI] [PubMed] [Google Scholar]
  19. Raeburn D., Hay D. W., Farmer S. G., Fedan J. S. Epithelium removal increases the reactivity of human isolated tracheal muscle to methacholine and reduces the effect of verapamil. Eur J Pharmacol. 1986 Apr 29;123(3):451–453. doi: 10.1016/0014-2999(86)90722-3. [DOI] [PubMed] [Google Scholar]
  20. Raeburn D., Hay D. W., Robinson V. A., Farmer S. G., Fleming W. W., Fedan J. S. The effect of verapamil is reduced in isolated airway smooth muscle preparations lacking the epithelium. Life Sci. 1986 Mar 3;38(9):809–816. doi: 10.1016/0024-3205(86)90597-7. [DOI] [PubMed] [Google Scholar]
  21. Ruff F., Zander J. F., Edoute Y., Santais M. C., Flavahan N. A., Verbeuren T. J., Vanhoutte P. M. Beta-2 adrenergic responses to tulobuterol in airway smooth muscle, vascular smooth muscle and adrenergic nerves. J Pharmacol Exp Ther. 1988 Jan;244(1):173–180. [PubMed] [Google Scholar]
  22. Shikano K., Berkowitz B. A. Endothelium-derived relaxing factor is a selective relaxant of vascular smooth muscle. J Pharmacol Exp Ther. 1987 Oct;243(1):55–60. [PubMed] [Google Scholar]
  23. Stuart-Smith K., Vanhoutte P. M. Heterogeneity in the effects of epithelium removal in the canine bronchial tree. J Appl Physiol (1985) 1987 Dec;63(6):2510–2515. doi: 10.1152/jappl.1987.63.6.2510. [DOI] [PubMed] [Google Scholar]
  24. Vanhoutte P. M. Airway epithelium and bronchial reactivity. Can J Physiol Pharmacol. 1987 Mar;65(3):448–450. doi: 10.1139/y87-076. [DOI] [PubMed] [Google Scholar]
  25. Vanhoutte P. M., Rubanyi G. M., Miller V. M., Houston D. S. Modulation of vascular smooth muscle contraction by the endothelium. Annu Rev Physiol. 1986;48:307–320. doi: 10.1146/annurev.ph.48.030186.001515. [DOI] [PubMed] [Google Scholar]
  26. Xue Q. F., Maurer R., Engel G. Selective distribution of beta- and alpha 1-adrenoceptors in rat lung visualized by autoradiography. Arch Int Pharmacodyn Ther. 1983 Dec;266(2):308–314. [PubMed] [Google Scholar]

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