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. 1988 Oct;43(10):756–761. doi: 10.1136/thx.43.10.756

Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells.

K B Leung 1, K C Flint 1, J Brostoff 1, B N Hudspith 1, N M Johnson 1, H Y Lau 1, W L Liu 1, F L Pearce 1
PMCID: PMC461499  PMID: 2462755

Abstract

Sodium cromoglycate and nedocromil sodium produced a dose dependent inhibition of histamine secretion from human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymatic dissociation of lung parenchyma. Both compounds were significantly more active against the lavage cells than against the dispersed lung cells, and nedocromil sodium was an order of magnitude more effective than sodium cromoglycate against both cell types. Tachyphylaxis was observed with the parenchymal cells but not with the lavage cells. Nedocromil sodium and sodium cromoglycate also inhibited histamine release from the lavage cells of patients with sarcoidosis and extrinsic asthma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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