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. 1988 Oct;43(10):784–786. doi: 10.1136/thx.43.10.784

Antileucoprotease in the developing fetal lung.

L N Willems 1, J A Kramps 1, P K Jeffery 1, J H Dijkman 1
PMCID: PMC461511  PMID: 3206386

Abstract

The distribution of antileucoprotease in the lungs of 25 fetuses of 9-40 weeks' gestation was studied with monoclonal antibodies and an indirect immunoperoxidase technique. Antileucoprotease was detected from 16 weeks in submucosal glands and collecting ducts in the trachea and main and lobar bronchi: it was also found in the surface epithelium of the trachea at 20 weeks, in main and lobar bronchi at 20 weeks, and in smaller bronchi at 20-25 weeks. Non-ciliated cells containing antileucoprotease were observed in the bronchiolar epithelium at 36 and 40 weeks. The results of this study indicate that antileucoprotease is available from birth. It may therefore form part of the first line of defence of the lung.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Christensen T. G., Korthy A. L., Snider G. L., Hayes J. A. Irreversible bronchial goblet cell metaplasia in hamsters with elastase-induced panacinar emphysema. J Clin Invest. 1977 Mar;59(3):397–404. doi: 10.1172/JCI108652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. De Water R., Willems L. N., Van Muijen G. N., Franken C., Fransen J. A., Dijkman J. H., Kramps J. A. Ultrastructural localization of bronchial antileukoprotease in central and peripheral human airways by a gold-labeling technique using monoclonal antibodies. Am Rev Respir Dis. 1986 May;133(5):882–890. [PubMed] [Google Scholar]
  3. Hyde D. M., Plopper C. G., Kass P. H., Alley J. L. Estimation of cell numbers and volumes of bronchiolar epithelium during rabbit lung maturation. Am J Anat. 1983 Jul;167(3):359–370. doi: 10.1002/aja.1001670306. [DOI] [PubMed] [Google Scholar]
  4. Mooren H. W., Kramps J. A., Franken C., Meijer C. J., Dijkman J. A. Localisation of a low-molecular-weight bronchial protease inhibitor in the peripheral human lung. Thorax. 1983 Mar;38(3):180–183. doi: 10.1136/thx.38.3.180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Plopper C. G., Alley J. L., Serabjitsingh C. J., Philpot R. M. Cytodifferentiation of the nonciliated bronchiolar epithelial (Clara) cell during rabbit lung maturation: an ultrastructural and morphometric study. Am J Anat. 1983 Jul;167(3):329–357. doi: 10.1002/aja.1001670305. [DOI] [PubMed] [Google Scholar]
  6. Snider G. L., Lucey E. C., Christensen T. G., Stone P. J., Calore J. D., Catanese A., Franzblau C. Emphysema and bronchial secretory cell metaplasia induced in hamsters by human neutrophil products. Am Rev Respir Dis. 1984 Jan;129(1):155–160. doi: 10.1164/arrd.1984.129.1.155. [DOI] [PubMed] [Google Scholar]
  7. Sykes D. A., Wilson R., Greenstone M., Currie D. C., Steinfort C., Cole P. J. Deleterious effects of purulent sputum sol on human ciliary function in vitro: at least two factors identified. Thorax. 1987 Apr;42(4):256–261. doi: 10.1136/thx.42.4.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Tegner H., Ohlsson K., Toremalm N. G., von Mecklenburg C. Effect of human leukocyte enzymes on tracheal mucosa and its mucociliary activity. Rhinology. 1979 Sep;17(3):199–206. [PubMed] [Google Scholar]
  9. Willems L. N., Kramps J. A., de Water R., Stijnen T., Fleuren G. J., Franken C., Dijkman J. H. Evaluation of antileukoprotease in surgical lung specimens. Eur J Respir Dis. 1986 Oct;69(4):242–247. [PubMed] [Google Scholar]
  10. Willems L. N., Otto-Verberne C. J., Kramps J. A., ten Have-Opbroek A. A., Dijkman J. H. Detection of antileukoprotease in connective tissue of the lung. Histochemistry. 1986;86(2):165–168. doi: 10.1007/BF00493382. [DOI] [PubMed] [Google Scholar]

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