Figure 5.

LMNA and LMNB1 associate with similar but also distinct chromatin domains. (A) IGV browser views of LMNA and LMNB1 ChIP-seq LiDs, and LMNB1 DamID LADs, on chromosome 2. LiDs are shown for HeLa cells (this study) and DamID LADs are shown for HT1080 cells⁴ (1) and fibroblasts² (2). RefSeq genes are shown. (B, C) Venn diagrams of genome coverage by LMNA LiDs in sonicated and MNase-digested chromatin, and (B) LMNB1 LADs identified by DamID in HT1080 cells or (C) LMNB1 LiDs mapped by ChIP-seq in HeLa cells.