Abstract
An investigation was carried out to determine whether the sensitivity of rat tracheal smooth muscle to contractile and relaxant drugs was affected by three weeks' treatment with subcutaneous budesonide before death. Budesonide treatment was associated with a lower thymus weight and a smaller gain in body weight than in control animals. There was, however, no difference in the carbachol concentration-response curves or maximum responses to carbachol of tracheal smooth muscle from control and budesonide treated rats. Isometric and isotonic recordings agreed in these respects. Glucocorticoid treatment did not increase the sensitivity of tracheal smooth muscle to the relaxant drugs terbutaline and enprofylline; if anything there was a tendency for terbutaline and enprofylline to be less potent after budesonide treatment. The data suggest that in vivo effects of glucocorticoids on airway responsiveness to bronchodilating and bronchoconstricting drugs are unlikely to be due to a direct effect on bronchial smooth muscle.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bryan M. H. The work of breathing during sleep in newborns [proceedings]. Am Rev Respir Dis. 1979 Feb;119(2 Pt 2):137–138. doi: 10.1164/arrd.1979.119.2P2.137. [DOI] [PubMed] [Google Scholar]
- Foster P. S., Goldie R. G., Paterson J. W. Effect of steroids on beta-adrenoceptor-mediated relaxation of pig bronchus. Br J Pharmacol. 1983 Feb;78(2):441–445. doi: 10.1111/j.1476-5381.1983.tb09409.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Geddes B. A., Lefcoe N. M. Respiratory smooth muscle relaxing effect of commercial steroid preparations. Am Rev Respir Dis. 1973 Mar;107(3):395–399. doi: 10.1164/arrd.1973.107.3.395. [DOI] [PubMed] [Google Scholar]
- Kerrebijn K. F., van Essen-Zandvliet E. E., Neijens H. J. Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma. J Allergy Clin Immunol. 1987 Apr;79(4):653–659. doi: 10.1016/s0091-6749(87)80163-x. [DOI] [PubMed] [Google Scholar]
- Kraan J., Koëter G. H., vd Mark T. W., Sluiter H. J., de Vries K. Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline. J Allergy Clin Immunol. 1985 Oct;76(4):628–636. doi: 10.1016/0091-6749(85)90786-9. [DOI] [PubMed] [Google Scholar]
- LEFCOE N. M. The effect of hydrocortisone hemisuccinate on tracheal smooth muscle of the guinea pig and cat. J Allergy. 1956 Jul;27(4):352–358. doi: 10.1016/0021-8707(56)90074-0. [DOI] [PubMed] [Google Scholar]
- Persson C. G. Development of safer xanthine drugs for treatment of obstructive airways disease. J Allergy Clin Immunol. 1986 Oct;78(4 Pt 2):817–824. doi: 10.1016/0091-6749(86)90067-9. [DOI] [PubMed] [Google Scholar]
- de Jongste J. C., Mons H., van Strik R., Bonta I. L., Kerrebijn K. F. Comparison of isometric and isotonic responses of human small airway smooth muscle in vitro. J Pharmacol Methods. 1987 Apr;17(2):165–171. doi: 10.1016/0160-5402(87)90027-1. [DOI] [PubMed] [Google Scholar]