Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1989 Feb;44(2):136–140. doi: 10.1136/thx.44.2.136

Cardiovascular and hypokalaemic effects of inhaled salbutamol, fenoterol, and isoprenaline.

J Crane 1, C Burgess 1, R Beasley 1
PMCID: PMC461717  PMID: 2928998

Abstract

The cardiovascular and hypokalaemic effects of equal doses of inhaled fenoterol, isoprenaline and salbutamol were compared in eight healthy male volunteers, in a double blind, placebo controlled study. Increasing doses of 400, 600, and 800 micrograms were given from a metered dose inhaler at 15 minute intervals, followed by measurements of heart rate, blood pressure, total electromechanical systole (as a measure of inotropic response), QTc interval, and plasma potassium concentration. After repeated inhalation, fenoterol resulted in significantly greater chronotropic, electrocardiographic, and hypokalaemic effects than either isoprenaline or salbutamol. The maximum inotropic effect of fenoterol was similar to that of isoprenaline.

Full text

PDF
136

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banner A. S., Sunderrajan E. V., Agarwal M. K., Addington W. W. Arrhythmogenic effects of orally administered bronchodilators. Arch Intern Med. 1979 Apr;139(4):434–437. [PubMed] [Google Scholar]
  2. Brittain R. T., Dean C. M., Jack D. Sympathomimetic bronchodilator drugs. Pharmacol Ther B. 1976;2(3):423–462. doi: 10.1016/0306-039x(76)90001-5. [DOI] [PubMed] [Google Scholar]
  3. Chapman K. R., Smith D. L., Rebuck A. S., Leenen F. H. Hemodynamic effects of an inhaled beta-2 agonist. Clin Pharmacol Ther. 1984 Jun;35(6):762–767. doi: 10.1038/clpt.1984.108. [DOI] [PubMed] [Google Scholar]
  4. Clausen T., Flatman J. A. Beta 2-adrenoceptors mediate the stimulating effect of adrenaline on active electrogenic Na-K-transport in rat soleus muscle. Br J Pharmacol. 1980 Apr;68(4):749–755. doi: 10.1111/j.1476-5381.1980.tb10868.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Conrad K. A. Effects of atropine on diastolic time. Circulation. 1981 Feb;63(2):371–377. doi: 10.1161/01.cir.63.2.371. [DOI] [PubMed] [Google Scholar]
  6. Haalboom J. R., Deenstra M., Struyvenberg A. Hypokalaemia induced by inhalation of fenoterol. Lancet. 1985 May 18;1(8438):1125–1127. doi: 10.1016/s0140-6736(85)92432-8. [DOI] [PubMed] [Google Scholar]
  7. Hassan S., Turner P. Systolic time intervals: a review of the method in the non-invasive investigation of cardiac function in health, disease and clinical pharmacology. Postgrad Med J. 1983 Jul;59(693):423–434. doi: 10.1136/pgmj.59.693.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Higgins R. M., Cookson W. O., Lane D. J., John S. M., McCarthy G. L., McCarthy S. T. Cardiac arrhythmias caused by nebulised beta-agonist therapy. Lancet. 1987 Oct 10;2(8563):863–864. doi: 10.1016/s0140-6736(87)91057-9. [DOI] [PubMed] [Google Scholar]
  9. Keating G., Mitchell E. A., Jackson R., Beaglehole R., Rea H. Trends in sales of drugs for asthma in New Zealand, Australia, and the United Kingdom, 1975-81. Br Med J (Clin Res Ed) 1984 Aug 11;289(6441):348–351. doi: 10.1136/bmj.289.6441.348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Krikler D. M., Curry P. V. Torsade De Pointes, an atypical ventricular tachycardia. Br Heart J. 1976 Feb;38(2):117–120. doi: 10.1136/hrt.38.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lewis R. P., Rittogers S. E., Froester W. F., Boudoulas H. A critical review of the systolic time intervals. Circulation. 1977 Aug;56(2):146–158. doi: 10.1161/01.cir.56.2.146. [DOI] [PubMed] [Google Scholar]
  12. Livesay J. J., Follette D. M., Fey K. H., Nelson R. L., DeLand E. C., Barnard R. J., Buckberg G. D. Optimizing myocardial supply/demand balance with alpha-adrenergic drugs during cardiopulmonary resuscitation. J Thorac Cardiovasc Surg. 1978 Aug;76(2):244–251. [PubMed] [Google Scholar]
  13. Neville E., Corris P. A., Vivian J., Nariman S., Gibson G. J. Nebulised salbutamol and angina. Br Med J (Clin Res Ed) 1982 Sep 18;285(6344):796–797. doi: 10.1136/bmj.285.6344.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Paterson J. W., Woolcock A. J., Shenfield G. M. Bronchodilator drugs. Am Rev Respir Dis. 1979 Nov;120(5):1149–1188. doi: 10.1164/arrd.1979.120.5.1149. [DOI] [PubMed] [Google Scholar]
  15. Scheinin M., Koulu M., Laurikainen E., Allonen H. Hypokalaemia and other non-bronchial effects of inhaled fenoterol and salbutamol: a placebo-controlled dose-response study in healthy volunteers. Br J Clin Pharmacol. 1987 Nov;24(5):645–653. doi: 10.1111/j.1365-2125.1987.tb03224.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sears M. R. Why are deaths from asthma increasing? Eur J Respir Dis Suppl. 1986;147:175–181. [PubMed] [Google Scholar]
  17. Speizer F. E., Doll R., Heaf P., Strang L. B. Investigation into use of drugs preceding death from asthma. Br Med J. 1968 Feb 10;1(5588):339–343. doi: 10.1136/bmj.1.5588.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Strauss M. H., Reeves R. A., Smith D. L., Leenen F. H. The role of cardiac beta-1 receptors in the hemodynamic response to a beta-2 agonist. Clin Pharmacol Ther. 1986 Jul;40(1):108–115. doi: 10.1038/clpt.1986.146. [DOI] [PubMed] [Google Scholar]
  19. Tandon M. K. Cardiopulmonary effects of fenoterol and salbutamol aerosols. Chest. 1980 Mar;77(3):429–431. doi: 10.1378/chest.77.3.429. [DOI] [PubMed] [Google Scholar]
  20. Wallenstein S., Zucker C. L., Fleiss J. L. Some statistical methods useful in circulation research. Circ Res. 1980 Jul;47(1):1–9. doi: 10.1161/01.res.47.1.1. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES