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Cellular Oncology: the Official Journal of the International Society for Cellular Oncology logoLink to Cellular Oncology: the Official Journal of the International Society for Cellular Oncology
. 2005 Nov 22;27(4):203–213. doi: 10.1155/2005/719412

The Role of Macrophages in Tumor Development

Gerben J van der Bij 1,2, Steven J Oosterling 1,2, Sybren Meijer 1, Robert H J Beelen 2, Marjolein van Egmond 1,2,*
PMCID: PMC4617500  PMID: 16308469

Abstract

Macrophages constitute a large proportion of the immune cell infiltrate, which is present in many tumors. Activation state of macrophages is greatly influenced by their environment, leading to different macrophage subsets with diverse functions. Although previously regarded as potent immune cells that are capable of destroying tumor cells, recent literature focuses on the ability of macrophages to promote tumor development due to secretion of mediators, like growth and angiogenic factors. It is now becoming increasingly clear that a complicated synergistic relationship exists between macrophages and malignant cells whereby tumor cells can affect macrophage phenotype, and vice versa. As such, macrophages and their contribution in cancer development are currently subject of debate.

Keywords: Cancer, macrophages, metastases, tumor associated macrophage, cytotoxicity


Articles from Cellular Oncology : the Official Journal of the International Society for Cellular Oncology are provided here courtesy of Wiley

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