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. 2015 Oct 20;10(10):e0141291. doi: 10.1371/journal.pone.0141291

Correction: Modified Clonidine Testing for Growth Hormone Stimulation Reveals α2-Adrenoreceptor Sub Sensitivity in Children with Idiopathic Growth Hormone Deficiency

Christian Willaschek, Sebastian Meint, Klaus Rager, Reiner Buchhorn
PMCID: PMC4617883  PMID: 26485273

There are errors in Table 2. Please see the corrected Table 2 here.

Clonidine Test (Age matched T-Tests)
Parameter Healthy Control Constitutional Growth Delay Growth Hormone Deficiency Small for Gestational Age
N 56 36 14 6
IgF1 [100–476 ng/ml] 86 ± 56 76 ± 42 43 ± 30
IgFPB3 [1900–5200 μg/l] 3075 ± 1076 2863 ± 1254 2538 ± 644
NT-pro-BNP [<289 ng/l] 162 ± 169 178 ± 172 177 ± 94
Heart Rate [bpm] 90 ± 15 85 ± 11*** 85 ± 11 83 ± 8*
SDNN [ms] 149 ± 51 112 ± 27** 117 ± 33* 142 ± 40
RMSSD[ms] 46 ± 18 51 ± 19* 50 ± 17 77 ± 15**
RMSSD Day 34 ± 15 41 ± 16** 37 ± 16 53 ± 14**
RMSSD Night 61 ± 26 65 ± 24 70 ± 24 108 ± 24**
Total Power 4957 ± 3029 3992 ± 2082 4000 ± 1873 7298 ± 2580**
Total Power Day 3889 ± 2747 3048 ± 1629 3286 ± 1863 4720 ± 1971*
Total Power Night 6287 ± 3843 5289 ± 3118 5111 ± 2391 10740 ± 3264**
VLF 2839 ± 2222 1960 ± 1327 2026 ± 1085 4831 ± 2678*
VLF Day 2256 ± 2016 743 ± 124 1666 ± 947 2710 ± 1601
VLF Night 3534 ± 2844 2699 ± 2412 2581 ± 1595 7553 ± 3833*
LFn 60 ± 8 52 ± 10* 55 ± 10 65 ± 12
LFn Day 65 ± 9 53 ± 9*** 59 ± 11 61 ± 12
LFn Night 56 ± 10,6 51 ± 14 53 ± 12 70,8 ± 13
HF 731 ± 350 817 ± 334 759 ± 295 747 ± 376
HF Day 456 ± 271 636 ± 371** 553 ± 331 633 ± 268*
HF Night 1100 ± 556 1082 ± 451 1079 ± 483 945 ± 671
HF/LF 0.61 ± 0.22 0,85 ± 0,36* 0,78 ± 0,32 0,51 ± 0,33
HF/LF Day 0,45 ± 0,18 0,77 ± 0,34*** 0,65 ± 0,32 0,59 ± 0,40
HF/LF Night 0,79 ± 0,38 0,99 ± 0,55 0,95 ± 0,66 0,43 ± 0,30*

Laboratory data, data on 24- hour HRV, daytime und night time HRV from children with CGD, GHD and SGA compared to age-matched healthy controls.IgF1: Insuline like growth factor, IgFPB3: Insuline like growth factor binding proteine, NT-pro-BNP: N-terminal propeptide of brain natriuretic peptide, SDNN: Standard deviation of NN-intervalls, RMSSD: Root mean square standard deviation of adjacent NN Intervals, VLF: Very low frequency (< 0.04 Hz),LF: low frequency (LF, 0.04–0.15 Hz) HF: high frequency (HF, 0.15–0.4 Hz)

*** p < 0.001

** p < 0.01

* p < 0.5

Reference


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