There are errors in Table 2. Please see the corrected Table 2 here.
| Clonidine Test (Age matched T-Tests) | ||||
|---|---|---|---|---|
| Parameter | Healthy Control | Constitutional Growth Delay | Growth Hormone Deficiency | Small for Gestational Age |
| N | 56 | 36 | 14 | 6 |
| IgF1 [100–476 ng/ml] | 86 ± 56 | 76 ± 42 | 43 ± 30 | |
| IgFPB3 [1900–5200 μg/l] | 3075 ± 1076 | 2863 ± 1254 | 2538 ± 644 | |
| NT-pro-BNP [<289 ng/l] | 162 ± 169 | 178 ± 172 | 177 ± 94 | |
| Heart Rate [bpm] | 90 ± 15 | 85 ± 11*** | 85 ± 11 | 83 ± 8* |
| SDNN [ms] | 149 ± 51 | 112 ± 27** | 117 ± 33* | 142 ± 40 |
| RMSSD[ms] | 46 ± 18 | 51 ± 19* | 50 ± 17 | 77 ± 15** |
| RMSSD Day | 34 ± 15 | 41 ± 16** | 37 ± 16 | 53 ± 14** |
| RMSSD Night | 61 ± 26 | 65 ± 24 | 70 ± 24 | 108 ± 24** |
| Total Power | 4957 ± 3029 | 3992 ± 2082 | 4000 ± 1873 | 7298 ± 2580** |
| Total Power Day | 3889 ± 2747 | 3048 ± 1629 | 3286 ± 1863 | 4720 ± 1971* |
| Total Power Night | 6287 ± 3843 | 5289 ± 3118 | 5111 ± 2391 | 10740 ± 3264** |
| VLF | 2839 ± 2222 | 1960 ± 1327 | 2026 ± 1085 | 4831 ± 2678* |
| VLF Day | 2256 ± 2016 | 743 ± 124 | 1666 ± 947 | 2710 ± 1601 |
| VLF Night | 3534 ± 2844 | 2699 ± 2412 | 2581 ± 1595 | 7553 ± 3833* |
| LFn | 60 ± 8 | 52 ± 10* | 55 ± 10 | 65 ± 12 |
| LFn Day | 65 ± 9 | 53 ± 9*** | 59 ± 11 | 61 ± 12 |
| LFn Night | 56 ± 10,6 | 51 ± 14 | 53 ± 12 | 70,8 ± 13 |
| HF | 731 ± 350 | 817 ± 334 | 759 ± 295 | 747 ± 376 |
| HF Day | 456 ± 271 | 636 ± 371** | 553 ± 331 | 633 ± 268* |
| HF Night | 1100 ± 556 | 1082 ± 451 | 1079 ± 483 | 945 ± 671 |
| HF/LF | 0.61 ± 0.22 | 0,85 ± 0,36* | 0,78 ± 0,32 | 0,51 ± 0,33 |
| HF/LF Day | 0,45 ± 0,18 | 0,77 ± 0,34*** | 0,65 ± 0,32 | 0,59 ± 0,40 |
| HF/LF Night | 0,79 ± 0,38 | 0,99 ± 0,55 | 0,95 ± 0,66 | 0,43 ± 0,30* |
Laboratory data, data on 24- hour HRV, daytime und night time HRV from children with CGD, GHD and SGA compared to age-matched healthy controls.IgF1: Insuline like growth factor, IgFPB3: Insuline like growth factor binding proteine, NT-pro-BNP: N-terminal propeptide of brain natriuretic peptide, SDNN: Standard deviation of NN-intervalls, RMSSD: Root mean square standard deviation of adjacent NN Intervals, VLF: Very low frequency (< 0.04 Hz),LF: low frequency (LF, 0.04–0.15 Hz) HF: high frequency (HF, 0.15–0.4 Hz)
*** p < 0.001
** p < 0.01
* p < 0.5
Reference
- 1. Willaschek C, Meint S, Rager K, Buchhorn R (2015) Modified Clonidine Testing for Growth Hormone Stimulation Reveals α2-Adrenoreceptor Sub Sensitivity in Children with Idiopathic Growth Hormone Deficiency. PLoS ONE 10(9): e0137643 doi: 10.1371/journal.pone.0137643 [DOI] [PMC free article] [PubMed] [Google Scholar]
