Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1989 Aug;44(8):660–667. doi: 10.1136/thx.44.8.660

Disturbance in respiratory mechanics in infants with bronchiolitis.

J Seidenberg 1, I B Masters 1, I Hudson 1, A Olinsky 1, P D Phelan 1
PMCID: PMC462002  PMID: 2799745

Abstract

The passive flow-volume and partial forced expiratory flow-volume techniques were used to assess pulmonary function in 14 spontaneously breathing infants with acute respiratory syncytial virus bronchiolitis. Two additional infants were studied while paralysed and ventilated. During the acute stage of the illness there was a significant reduction in forced expiratory flow rates and an increase in respiratory resistance. Although the mean thoracic gas volume for the group was increased, five infants did not compensate for their airways obstruction by hyperinflation. Curvilinear passive flow-volume curves were seen in three of the 14 non-ventilated infants and in both ventilated infants. At follow up three to four months later all passive flow-volume curves were linear. There was a significant reduction in hyperinflation and an increase in forced expiratory flow rates, but values still differed significantly from those in normal infants.

Full text

PDF
660

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adler S. M., Wohl M. E. Flow-volume relationship at low lung volumes in healthy term newborn infants. Pediatrics. 1978 Apr;61(4):636–640. [PubMed] [Google Scholar]
  2. Beardsmore C. S., Helms P., Stocks J., Hatch D. J., Silverman M. Improved esophageal balloon technique for use in infants. J Appl Physiol Respir Environ Exerc Physiol. 1980 Oct;49(4):735–742. doi: 10.1152/jappl.1980.49.4.735. [DOI] [PubMed] [Google Scholar]
  3. Beardsmore C. S., Stocks J., Silverman M. Problems in measurement of thoracic gas volume in infancy. J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr;52(4):995–999. doi: 10.1152/jappl.1982.52.4.995. [DOI] [PubMed] [Google Scholar]
  4. Collett P. W., Brancatisano A. P., Engel L. A. Upper airway dimensions and movements in bronchial asthma. Am Rev Respir Dis. 1986 Jun;133(6):1143–1149. doi: 10.1164/arrd.1986.133.6.1143. [DOI] [PubMed] [Google Scholar]
  5. Godfrey S., Beardsmore C. S., Maayan C., Bar-Yishay E. Can thoracic gas volume be measured in infants with airways obstruction? Am Rev Respir Dis. 1986 Feb;133(2):245–251. doi: 10.1164/arrd.1986.133.2.245. [DOI] [PubMed] [Google Scholar]
  6. Gottfried S. B., Rossi A., Calverley P. M., Zocchi L., Milic-Emili J. Interrupter technique for measurement of respiratory mechanics in anesthetized cats. J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):681–690. doi: 10.1152/jappl.1984.56.3.681. [DOI] [PubMed] [Google Scholar]
  7. Helms P. Problems with plethysmographic estimation of lung volume in infants and young children. J Appl Physiol Respir Environ Exerc Physiol. 1982 Sep;53(3):698–702. doi: 10.1152/jappl.1982.53.3.698. [DOI] [PubMed] [Google Scholar]
  8. Hughes D. M., Lesouëf P. N., Landau L. I. Effect of salbutamol on respiratory mechanics in bronchiolitis. Pediatr Res. 1987 Jul;22(1):83–86. doi: 10.1203/00006450-198707000-00019. [DOI] [PubMed] [Google Scholar]
  9. Landau L. I., Phelan P. D. Evaluation of two techniques for measurement of respiratory resistance by forced oscillation. A study in young subjects with obstructive lung disease. Thorax. 1973 Mar;28(2):136–141. doi: 10.1136/thx.28.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Le Souëf P. N., Hughes D. M., Landau L. I. Effect of compression pressure on forced expiratory flow in infants. J Appl Physiol (1985) 1986 Nov;61(5):1639–1646. doi: 10.1152/jappl.1986.61.5.1639. [DOI] [PubMed] [Google Scholar]
  11. Lesouef P. N., England S. J., Bryan A. C. Passive respiratory mechanics in newborns and children. Am Rev Respir Dis. 1984 Apr;129(4):552–556. [PubMed] [Google Scholar]
  12. Lopes J., Muller N. L., Bryan M. H., Bryan A. C. Importance of inspiratory muscle tone in maintenance of FRC in the newborn. J Appl Physiol Respir Environ Exerc Physiol. 1981 Oct;51(4):830–834. doi: 10.1152/jappl.1981.51.4.830. [DOI] [PubMed] [Google Scholar]
  13. Mansell A. L., Bryan A. C., Levison H. Relationship of lung recoil to lung volume and maximum expiratory flow in normal children. J Appl Physiol Respir Environ Exerc Physiol. 1977 Jun;42(6):817–823. doi: 10.1152/jappl.1977.42.6.817. [DOI] [PubMed] [Google Scholar]
  14. Masters I. B., Seidenberg J., Hudson I., Phelan P. D., Olinsky A. Longitudinal study of lung mechanics in normal infants. Pediatr Pulmonol. 1987 Jan-Feb;3(1):3–7. doi: 10.1002/ppul.1950030104. [DOI] [PubMed] [Google Scholar]
  15. Mortola J. P., Fisher J. T., Smith B., Fox G., Weeks S. Dynamics of breathing in infants. J Appl Physiol Respir Environ Exerc Physiol. 1982 May;52(5):1209–1215. doi: 10.1152/jappl.1982.52.5.1209. [DOI] [PubMed] [Google Scholar]
  16. Olinsky A., Bryan A. C., Bryan M. H. A simple method of measuring total respiratory system compliance in newborn infants. S Afr Med J. 1976 Jan 31;50(5):128–130. [PubMed] [Google Scholar]
  17. Phelan P. D., Williams H. E. Ventilatory studies in healthy infants. Pediatr Res. 1969 Sep;3(5):425–432. doi: 10.1203/00006450-196909000-00005. [DOI] [PubMed] [Google Scholar]
  18. Prendiville A., Green S., Silverman M. Paradoxical response to nebulised salbutamol in wheezy infants, assessed by partial expiratory flow-volume curves. Thorax. 1987 Feb;42(2):86–91. doi: 10.1136/thx.42.2.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Radford M. Effect of salbutamol in infants with wheezy bronchitis. Arch Dis Child. 1975 Jul;50(7):535–538. doi: 10.1136/adc.50.7.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Silverman M., Prendiville A., Green S. Partial expiratory flow-volume curves in infancy: technical aspects. Bull Eur Physiopathol Respir. 1986 May-Jun;22(3):257–262. [PubMed] [Google Scholar]
  21. Stocks J., Levy N. M., Godfrey S. A new apparatus for the accurate measurement of airway resistance in infancy. J Appl Physiol Respir Environ Exerc Physiol. 1977 Jul;43(1):155–159. doi: 10.1152/jappl.1977.43.1.155. [DOI] [PubMed] [Google Scholar]
  22. Taussig L. M., Landau L. I., Godfrey S., Arad I. Determinants of forced expiratory flows in newborn infants. J Appl Physiol Respir Environ Exerc Physiol. 1982 Nov;53(5):1220–1227. doi: 10.1152/jappl.1982.53.5.1220. [DOI] [PubMed] [Google Scholar]
  23. Wohl M. E., Stigol L. C., Mead J. Resistance of the total respiratory system in healthy infants and infants with bronchiolitis. Pediatrics. 1969 Apr;43(4):495–509. [PubMed] [Google Scholar]
  24. Woolcock A. J., Read J. Improvement in bronchial asthma not reflected in forced expiratory volume. Lancet. 1965 Dec 25;2(7426):1323–1325. doi: 10.1016/s0140-6736(65)92343-3. [DOI] [PubMed] [Google Scholar]
  25. Zin W. A., Pengelly L. D., Milic-Emili J. Single-breath method for measurement of respiratory mechanics in anesthetized animals. J Appl Physiol Respir Environ Exerc Physiol. 1982 May;52(5):1266–1271. doi: 10.1152/jappl.1982.52.5.1266. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES