Skip to main content
Thorax logoLink to Thorax
. 1989 Sep;44(9):711–715. doi: 10.1136/thx.44.9.711

Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone.

P Camus 1, J N Lombard 1, M Perrichon 1, F Piard 1, J C Guérin 1, F B Thivolet 1, L Jeannin 1
PMCID: PMC462050  PMID: 2588206

Abstract

Two patients, treated with acebutolol and amiodarone respectively, developed a disease clinically, radiologically, and pathologically indistinguishable from bronchiolitis obliterans organising pneumonia. In one case recovery followed discontinuation of acebutolol; in the other case cessation of amiodarone had no effect, and corticosteroids were required. In addition to these patients, several cases of bronchiolitis obliterans organising pneumonia have been reported during treatment with gold salts, amiodarone, and miscellaneous other drugs. Taken together, this information supports the view that bronchiolitis obliterans organising pneumonia may be a form of response by the lungs to insult by drugs.

Full text

PDF
711

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams P. C., Gibson G. J., Morley A. R., Wright A. J., Corris P. A., Reid D. S., Campbell R. W. Amiodarone pulmonary toxicity: clinical and subclinical features. Q J Med. 1986 May;59(229):449–471. [PubMed] [Google Scholar]
  2. Bense L., Wiman L. G., Steiner E., Hjerpe A. Pulmonary side effects after treatment with barbiturates. Eur J Respir Dis. 1986 Jul;69(1):61–62. [PubMed] [Google Scholar]
  3. Camp M., Mehta J. B., Whitson M. Bronchiolitis obliterans and Nocardia asteroides infection of the lung. Chest. 1987 Dec;92(6):1107–1108. doi: 10.1378/chest.92.6.1107. [DOI] [PubMed] [Google Scholar]
  4. Camus P., Mehendale H. M. Pulmonary sequestration of amiodarone and desethylamiodarone. J Pharmacol Exp Ther. 1986 Jun;237(3):867–873. [PubMed] [Google Scholar]
  5. Chandler P. W., Shin M. S., Friedman S. E., Myers J. L., Katzenstein A. L. Radiographic manifestations of bronchiolitis obliterans with organizing pneumonia vs usual interstitial pneumonia. AJR Am J Roentgenol. 1986 Nov;147(5):899–906. doi: 10.2214/ajr.147.5.899. [DOI] [PubMed] [Google Scholar]
  6. Colgan T., Simon G. T., Kay J. M., Pugsley S. O., Eydt J. Amiodarone pulmonary toxicity. Ultrastruct Pathol. 1984;6(2-3):199–207. doi: 10.3109/01913128409018574. [DOI] [PubMed] [Google Scholar]
  7. Cooper J. A., Jr, White D. A., Matthay R. A. Drug-induced pulmonary disease. Part 2: Noncytotoxic drugs. Am Rev Respir Dis. 1986 Mar;133(3):488–505. doi: 10.1164/arrd.1986.133.3.488. [DOI] [PubMed] [Google Scholar]
  8. Davison A. G., Heard B. E., McAllister W. A., Turner-Warwick M. E. Cryptogenic organizing pneumonitis. Q J Med. 1983 Summer;52(207):382–394. [PubMed] [Google Scholar]
  9. Epler G. R., Colby T. V., McLoud T. C., Carrington C. B., Gaensler E. A. Bronchiolitis obliterans organizing pneumonia. N Engl J Med. 1985 Jan 17;312(3):152–158. doi: 10.1056/NEJM198501173120304. [DOI] [PubMed] [Google Scholar]
  10. Fort J. G., Scovern H., Abruzzo J. L. Intravenous cyclophosphamide and methylprednisolone for the treatment of bronchiolitis obliterans and interstitial fibrosis associated with crysotherapy. J Rheumatol. 1988;15(5):850–854. [PubMed] [Google Scholar]
  11. Gefter W. B., Epstein D. M., Pietra G. G., Miller W. T. Lung disease caused by amiodarone, a new antiarrythmic agent. Radiology. 1983 May;147(2):339–344. doi: 10.1148/radiology.147.2.6836114. [DOI] [PubMed] [Google Scholar]
  12. Guerry-Force M. L., Müller N. L., Wright J. L., Wiggs B., Coppin C., Pare P. D., Hogg J. C. A comparison of bronchiolitis obliterans with organizing pneumonia, usual interstitial pneumonia, and small airways disease. Am Rev Respir Dis. 1987 Mar;135(3):705–712. doi: 10.1164/arrd.1987.135.3.705. [DOI] [PubMed] [Google Scholar]
  13. Joelson J., Kluger J., Cole S., Conway M. Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy. Chest. 1984 Feb;85(2):284–286. doi: 10.1378/chest.85.2.284. [DOI] [PubMed] [Google Scholar]
  14. Katzenstein A. L., Myers J. L., Prophet W. D., Corley L. S., 3rd, Shin M. S. Bronchiolitis obliterans and usual interstitial pneumonia. A comparative clinicopathologic study. Am J Surg Pathol. 1986 Jun;10(6):373–381. doi: 10.1097/00000478-198606000-00002. [DOI] [PubMed] [Google Scholar]
  15. Marchlinski F. E., Gansler T. S., Waxman H. L., Josephson M. E. Amiodarone pulmonary toxicity. Ann Intern Med. 1982 Dec;97(6):839–845. doi: 10.7326/0003-4819-97-6-839. [DOI] [PubMed] [Google Scholar]
  16. McCormick J., Cole S., Lahirir B., Knauft F., Cohen S., Yoshida T. Pneumonitis caused by gold salt therapy: evidence for the role of cell-mediated immunity in its pathogenesis. Am Rev Respir Dis. 1980 Jul;122(1):145–152. doi: 10.1164/arrd.1980.122.1.145. [DOI] [PubMed] [Google Scholar]
  17. Myers J. L., Kennedy J. I., Plumb V. J. Amiodarone lung: pathologic findings in clinically toxic patients. Hum Pathol. 1987 Apr;18(4):349–354. doi: 10.1016/s0046-8177(87)80164-8. [DOI] [PubMed] [Google Scholar]
  18. Olson L. K., Forrest J. V., Friedman P. J., Kiser P. E., Henschke C. I. Pneumonitis after amiodarone therapy. Radiology. 1984 Feb;150(2):327–330. doi: 10.1148/radiology.150.2.6691083. [DOI] [PubMed] [Google Scholar]
  19. Patel R. C., Dutta D., Schonfeld S. A. Free-base cocaine use associated with bronchiolitis obliterans organizing pneumonia. Ann Intern Med. 1987 Aug;107(2):186–187. doi: 10.7326/0003-4819-107-2-186. [DOI] [PubMed] [Google Scholar]
  20. Swinburn C. R., Jackson G. J., Cobden I., Ashcroft T., Morritt G. N., Corris P. A. Bronchiolitis obliterans organising pneumonia in a patient with ulcerative colitis. Thorax. 1988 Sep;43(9):735–736. doi: 10.1136/thx.43.9.735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Williams T., Eidus L., Thomas P. Fibrosing alveolitis, bronchiolitis obliterans, and sulfasalazine therapy. Chest. 1982 Jun;81(6):766–768. doi: 10.1378/chest.81.6.766. [DOI] [PubMed] [Google Scholar]
  22. Yousem S. A., Colby T. V., Carrington C. B. Lung biopsy in rheumatoid arthritis. Am Rev Respir Dis. 1985 May;131(5):770–777. doi: 10.1164/arrd.1985.131.5.770. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES