Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1989 Nov;44(11):952–955. doi: 10.1136/thx.44.11.952

Generalised non-reactive tuberculosis: a clinicopathological study of four patients.

R Singh 1, R C Joshi 1, J Christie 1
PMCID: PMC462154  PMID: 2595638

Abstract

Non-reactive tuberculosis is a histopathological entity characterised by foci of necrosis surrounded by normal parenchyma and absence of epithelioid cell granulomas. The clinical presentation and necropsy findings in four patients are described and the pathogenesis of the disease discussed.

Full text

PDF
952

Images in this article

954Image
on p.954
954Image
on p.954

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BANYAI A. L. Diabetes and tuberculosis. Dis Chest. 1959 Sep;36:238–242. doi: 10.1378/chest.36.3.238. [DOI] [PubMed] [Google Scholar]
  2. Brown C. A., Brown I. N. Mycobacterium bovis, BCG, modulation of murine antibody responses: influence of dose and degree of aggregation of live or dead organisms. Br J Exp Pathol. 1982 Apr;63(2):133–143. [PMC free article] [PubMed] [Google Scholar]
  3. Claman H. N. Corticosteroids and lymphoid cells. N Engl J Med. 1972 Aug 24;287(8):388–397. doi: 10.1056/NEJM197208242870806. [DOI] [PubMed] [Google Scholar]
  4. Hansson V., Svane S., Torgersen O. Non-reactive tuberculosis and malignant blood disorders. J Oslo City Hosp. 1972 Jan;22(1):5–15. [PubMed] [Google Scholar]
  5. Lehmann V., Freudenberg M. A., Galanos C. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice. J Exp Med. 1987 Mar 1;165(3):657–663. doi: 10.1084/jem.165.3.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lenzini L., Rottoli P., Rottoli L. The spectrum of human tuberculosis. Clin Exp Immunol. 1977 Feb;27(2):230–237. [PMC free article] [PubMed] [Google Scholar]
  7. MONTES M., PHILLIPS C. Nonreactive tuberculosis. Am Rev Tuberc. 1959 Mar;79(3):362–370. doi: 10.1164/artpd.1959.79.3.362. [DOI] [PubMed] [Google Scholar]
  8. O'BRIEN J. R. Non-reactive tuberculosis. J Clin Pathol. 1954 Aug;7(3):216–225. doi: 10.1136/jcp.7.3.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Paar J. A., Scheinman M. M., Weaver R. A. Disseminated nonreactive tuberculosis with basophilia, leukemoid reaction and terminal pancytopenia. N Engl J Med. 1966 Feb 10;274(6):335–335. doi: 10.1056/NEJM196602102740608. [DOI] [PubMed] [Google Scholar]
  10. Rook G. A. Role of activated macrophages in the immunopathology of tuberculosis. Br Med Bull. 1988 Jul;44(3):611–623. doi: 10.1093/oxfordjournals.bmb.a072271. [DOI] [PubMed] [Google Scholar]
  11. SPAIN D. M., MOLOMUT N. Effects of cortisone on the development of tuberculous lesions in guinea pigs and on their modification by streptomycin therapy. Am Rev Tuberc. 1950 Oct;62(4):337–344. doi: 10.1164/art.1950.62.4.337. [DOI] [PubMed] [Google Scholar]
  12. Staples W. G., Gétaz E. P., Botha D. Disseminated tuberculosis, bone marrow necrosis and lymphoma: a case report. S Afr Med J. 1977 Oct 15;52(17):680–683. [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES