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. 2014 Dec 18;7(1):129–137. doi: 10.4161/19420862.2014.985489

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© MedImmune

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — In vivo efficacy of antibody ZY0NP0-E06 in Alternaria alternata challenge model of asthma. ZY0NP0-E06 or isotype control (mIgG1) were dosed at 30 mg/kg intra-peritoneal 1 day and 1 hour prior to intranasal challenge with 25 μg Alternaria alternata extract. Eosinophil numbers (A) and IL-5 levels (B) were measured in the bronchoalveolar fluid 24 hr post-challenge. Error bars correspond to ± standard error of the mean, and represent the composite of 2 independent experiments with 7–12 mice per group. Significance was determined by 1 way ANOVA with a Tukey's multiple comparison test. * 0.05 > p > 0.01, ** 0.001 > p > 0.01, *** 0.0001> p >0.001 and ****0.0001 > p.