EDITOR-IN-CHIEF
Brian W. Matthews
University of Oregon
FOUNDING EDITOR
Hans Neurath
ASSOCIATE EDITORS
Hideo Akutsu
Osaka University
Dorothy Beckett
University of Maryland
Markus Gruetter
University of Zurich
Ron Levy
Temple University
Albert J.R. Heck Utrecht Institute for Pharmaceutical Sciences
Utrecht University
Dr. Yigong Shi
School of Life Science Tsinghua University
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Douglas Henry Juers
Whitman College
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Wiley
EDITORIAL ADVISORY BOARD
Ivet Bahar
University of Pittsburgh
P. Balaram
Indian Institute of Science
Maurizio Brunori
Sapienza-University of Rome
Zengyi Chang
Peking University
David Christianson
University of Pennsylvania
Andrew J. Doig
University of Manchester
Arne Elofsson
Stockholm University
Elisabeth Sauer-Eriksson
Umea° University
Mark Gerstein
Yale University
Lila Gierasch
University of Massachusetts
Yuji Goto
Osaka University
Gerald Hazelbauer
University of Missouri-Columbia
Yoshiki Higuchi
University Hyogo
Mei Hong
Iowa State University
Joel Janin
Universite´ Paris - Sud
Andrzej Joachimiak
Argonne National Laboratory
Neville Kallenbach
New York University
Igor Kaltashov
University of Massachusetts, Amherst
Olivier Lichtarge
Baylor College of Medicine
Andreas Matouschek
Northwestern University
Stephen Matthews
Imperial College
Hiroyuki Noji
University of Tokyo
Michael W. Parker
ACRF Rational Drug Discovery Centre
Kevin Plaxco
University of California, Santa
Barbara
Carol B. Post
Purdue University
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University of Wisconsin-Madison
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Stony Brook University
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Oxford Centre for Molecular Sciences
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EMBL, Heidelberg
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Wake Forest University
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Massachusetts Institute of
Technology
Brenda Schulman
St. Jude Children’s Research Hospital
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Tsinghua University School of Medicine
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University of California, San Francisco
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Georgia Institute of Technology
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University of Alberta
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Weizmann Institute of Science
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University of Sydney
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University of South Florida
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University of California, San Francisco
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University of Oklahoma
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University of York
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University of British Columbia
Cynthia Wolberger
Johns Hopkins University School of Medicine
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University of California, Los Angeles
Xuejun Cai Zhang
National Laboratory of Macromolecules Chinese Academy of Sciences
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Reviews
1549 Insights into vaccine development for acquired immune deficiency syndrome from crystal structures of human immunodeficiency virus-1 gp41 and equine infectious anemia virus gp45
Liangwei Duan, Jiansen Du, and Xinqi Liu
1560 Energy coupling mechanisms of MFS transporters
Xuejun C. Zhang, Yan Zhao, Jie Heng, and Daohua Jiang
Articles
1580 Nonspecific yet decisive: Ubiquitination can affect the native-state dynamics of the modified protein
Yulian Gavrilov, Tzachi Hagai, and Yaakov Levy
1593 Molecular architecture of KedS8, a sugar N-methyltransferase from Streptoalloteichus sp. ATCC 53650
Nathan A. Delvaux, James B. Thoden, and Hazel M. Holden
1600 Cofactor-induced reversible folding of Flavodoxin-4 from Lactobacillus acidophilus Samit Kumar Dutta, Pedro Serrano, Michael Geralt, Herbert L. Axelrod,
Qingping Xu, Scott A. Lesley, Adam Godzik, Ashley M. Deacon, Marc-André Elsliger, Ian A. Wilson, and Kurt W€uthrich
1609 Structure of the external aldimine form of PglE, an aminotransferase required for N,N’-diacetylbacillosamine biosynthesis
Alexander S. Riegert, N. Martin Young, David C. Watson, James B. Thoden, and Hazel M. Holden
1617 Hypothetical protein CT398 (CdsZ) interacts with σ54 (RpoN)-holoenzyme and the type III secretion export apparatus in Chlamydia trachomatis
Michael L. Barta, Kevin P. Battaile, Scott Lovell, and P. Scott Hefty
1633 Biochemical studies on WbcA, a sugar epimerase from Yersinia enterocolitica
Ari J. Salinger, Haley A. Brown, James B. Thoden, and Hazel M. Holden
1640 Mass spectrometry based analysis of human plasma-derived factor X revealed novel post-translational modifications
Guillaume Chevreux, Nolwenn Tilly, Valegh Faid, and Nicolas Bihoreau
1649 GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA
Lorna Wilkinson-White, Krystal L. Lester, Nina Ripin, David A. Jacques, J. Mitchell Guss, and Jacqueline M. Matthews
1660 Structure mediation in substrate binding and post-translational processing of penicillin acylases: Information from mutant structures of Kluyvera citrophila penicillin G acylase
Deepak Chand, NishantKumar Varshney, Sureshkumar Ramasamy, Priyabrata Panigrahi, James A. Brannigan, Anthony J. Wilkinson, and Suresh C. G.
1671 Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature
Nicole M. Milkovic, Jonathan Catazaro, Jiusheng Lin, Steven Halouska, James L. Kizziah, Sara Basiaga, Ronald L. Cerny, Robert Powers, and Mark A. Wilson
Methods and Applications
1686 A new method for detection of tumor driver-dependent changes of protein sialylation in a colon cancer cell line reveals nectin-3 as TGFBR2 target
Jennifer Lee, Uwe Warnken, Martina Schn€olzer, Johannes Gebert, and Jürgen Kopitz
For the Record
1695 Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression
Jacob B. Bale, Rachel U. Park, Yuxi Liu, Shane Gonen, Tamir Gonen, Duilio Cascio, Neil P. King, Todd O. Yeates, and David Baker
1702 Diffusion accessibility as a method for visualizing macromolecular surface geometry
Yingssu Tsai, Thomas Holton, and Todd O. Yeates