Table 3.

Parameters for cynomolgous monkey QBP359 – CCL21 model

Parameter Name	Notation	Value	Comments
Free Ab Clearance	CLab	0.0164 L/day	Fixed based on CLab for “typical” IgG1 mAb in 70 kg human= 0.174 L/d, and allometrically scaled to Cyno Monkeys (3 kg), as in Methods
Central Serum CompartmentVolume	V1	0.1414 L	Fixed based on V1 for “typical” IgG1 mAb in 70 kg human= 3.3 L, and allometrically scaled to Cyno Monkeys (3 kg), as in Methods
Peripheral Compartment Volume	V2	0.1161 L	Fixed based on V2 for “typical” IgG1 mAb in 70 kg human= 2.71 L, and allometrically scaled to Cyno Monkeys (3 kg), as in Methods
Free Ab / Complex Inter-compartmental Exchange	Qab	0.0524 L/day	Fixed based on Qab for “typical” IgG1 mAb in 70 kg human= 0.174 L/d, and allometrically scaled to Cyno Monkeys (3 kg), as in Methods
Complex Clearance	CLc	0.1102 L/day (10.3% CV)	Estimated by fitting to data. Parameter value indicated for a 3 kg monkey. For a 70 kg human estimated to be 1.17 L/day, based on allometric scaling.
Target Synthesis Rate	RLIt	58.7 nmole/d (7.9 % CV)	Estimated by fitting to data for a 3 kg monkey
Target Inter-compartmental Exchange	Qt	0.008 L/d (30.7% CV)	Estimated by fitting to data for a 3 kg monkey. For a 70 kg human estimated to be 0.0658 L/d, based on allometric scaling.
Target Clearance	CLt	0.4003 L/d (13.8% CV)	Estimated by fitting to data for a 3 kg monkey. For a 70 kg human estimated to be 4.25 L/d, based on allometric scaling.
Ab – Target Dissociation constant	KD	0.026 nM	Fixed based on in-vitro measurements (could not be estimated)