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. 2014 Oct 30;7(1):199–211. doi: 10.4161/19420862.2014.979081

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

© Chien-Hsing Chang, Yang Wang, Pankaj Gupta, and David M Goldenberg

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — Evaluation of growth-inhibition and apoptosis in D1–1 and Ramos cells. Cell viability determined by the MTS assay after 4-day incubation for (A) the Dried-I format of epratuzumab (hLL2*) or labetuzumab (hMN-14*) and (B) the Wet-I format of epratuzumab (hLL2) or labetuzumab (hMN-14). Apoptosis as determine by Annexin V staining (C) following the indicated treatments of D1–1 and Ramos cells for 24 and 48 h, respectively. (D) Plate-immobilized F(ab’)₂ of epratuzumab (hLL2 F(ab’)₂*) effectively induced apoptosis (left panel) and inhibited proliferation (right panel) in D1–1 cells as determined by the annexin V assay at 24 h and the MTS assay after 4 days, respectively. Error bars represent standard deviation (SD), where n = 3. Significant differences compared to untreated or nonspecific antibody are indicated with ^ (P < 0.005) and # (P < 0.05).