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. 1990 Mar;45(3):161–163. doi: 10.1136/thx.45.3.161

What is the role of the eosinophil?

P Venge 1
PMCID: PMC462375  PMID: 2184532

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Selected References

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  1. Ackerman S. J., Loegering D. A., Gleich G. J. The human eosinophil Charcot-Leyden crystal protein: biochemical characteristics and measurement by radioimmunoassay. J Immunol. 1980 Nov;125(5):2118–2126. [PubMed] [Google Scholar]
  2. Bruynzeel P. L., Kok P. T., Viëtor R. J., Verhagen J. On the optimal conditions of LTC4 formation by human eosinophils in vitro. Prostaglandins Leukot Med. 1985 Oct;20(1):11–22. doi: 10.1016/0262-1746(85)90090-3. [DOI] [PubMed] [Google Scholar]
  3. Butterworth A. E., Wassom D. L., Gleich G. J., Loegering D. A., David J. R. Damage to schistosomula of Schistosoma mansoni induced directly by eosinophil major basic protein. J Immunol. 1979 Jan;122(1):221–229. [PubMed] [Google Scholar]
  4. Carlson M. G., Peterson C. G., Venge P. Human eosinophil peroxidase: purification and characterization. J Immunol. 1985 Mar;134(3):1875–1879. [PubMed] [Google Scholar]
  5. Dahl R., Venge P. Enhancement of urokinase-induced plasminogen activation by the cationic protein of human eosinophil granulocytes. Thromb Res. 1979;14(4-5):599–608. doi: 10.1016/0049-3848(79)90115-4. [DOI] [PubMed] [Google Scholar]
  6. De Monchy J. G., Kauffman H. F., Venge P., Koëter G. H., Jansen H. M., Sluiter H. J., De Vries K. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis. 1985 Mar;131(3):373–376. doi: 10.1164/arrd.1985.131.3.373. [DOI] [PubMed] [Google Scholar]
  7. Diaz P., Galleguillos F. R., Gonzalez M. C., Pantin C. F., Kay A. B. Bronchoalveolar lavage in asthma: the effect of disodium cromoglycate (cromolyn) on leukocyte counts, immunoglobulins, and complement. J Allergy Clin Immunol. 1984 Jul;74(1):41–48. doi: 10.1016/0091-6749(84)90085-x. [DOI] [PubMed] [Google Scholar]
  8. Durack D. T., Ackerman S. J., Loegering D. A., Gleich G. J. Purification of human eosinophil-derived neurotoxin. Proc Natl Acad Sci U S A. 1981 Aug;78(8):5165–5169. doi: 10.1073/pnas.78.8.5165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Durham S. R., Kay A. B. Eosinophils, bronchial hyperreactivity and late-phase asthmatic reactions. Clin Allergy. 1985 Sep;15(5):411–418. doi: 10.1111/j.1365-2222.1985.tb02290.x. [DOI] [PubMed] [Google Scholar]
  10. Filley W. V., Holley K. E., Kephart G. M., Gleich G. J. Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma. Lancet. 1982 Jul 3;2(8288):11–16. doi: 10.1016/s0140-6736(82)91152-7. [DOI] [PubMed] [Google Scholar]
  11. Fredens K., Dahl R., Venge P. Eosinophils and cellular injury: the Gordon phenomenon as a model. N Engl Reg Allergy Proc. 1985 Fall;6(4):346–351. doi: 10.2500/108854185779109115. [DOI] [PubMed] [Google Scholar]
  12. Fredens K., Tøttrup A., Kristensen I. B., Dahl R., Jacobsen N. O., Funch-Jensen P., Thommesen P. Severe destruction of esophageal nerves in a patient with achalasia secondary to gastric cancer. A possible role of eosinophil neurotoxic proteins. Dig Dis Sci. 1989 Feb;34(2):297–303. doi: 10.1007/BF01536066. [DOI] [PubMed] [Google Scholar]
  13. Frigas E., Gleich G. J. The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol. 1986 Apr;77(4):527–537. doi: 10.1016/0091-6749(86)90341-6. [DOI] [PubMed] [Google Scholar]
  14. Frigas E., Loegering D. A., Gleich G. J. Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium. Lab Invest. 1980 Jan;42(1):35–43. [PubMed] [Google Scholar]
  15. Gleich G. J., Adolphson C. R. The eosinophilic leukocyte: structure and function. Adv Immunol. 1986;39:177–253. doi: 10.1016/s0065-2776(08)60351-x. [DOI] [PubMed] [Google Scholar]
  16. Gleich G. J., Flavahan N. A., Fujisawa T., Vanhoutte P. M. The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity. J Allergy Clin Immunol. 1988 May;81(5 Pt 1):776–781. doi: 10.1016/0091-6749(88)90931-1. [DOI] [PubMed] [Google Scholar]
  17. Gleich G. J., Loegering D. A., Bell M. P., Checkel J. L., Ackerman S. J., McKean D. J. Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease. Proc Natl Acad Sci U S A. 1986 May;83(10):3146–3150. doi: 10.1073/pnas.83.10.3146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Gleich G. J., Loegering D. A., Mann K. G., Maldonado J. E. Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils. J Clin Invest. 1976 Mar;57(3):633–640. doi: 10.1172/JCI108319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Gullberg U., Widegren B., Arnason U., Egesten A., Olsson I. The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity. Biochem Biophys Res Commun. 1986 Sep 30;139(3):1239–1242. doi: 10.1016/s0006-291x(86)80310-2. [DOI] [PubMed] [Google Scholar]
  20. Harlin S. L., Ansel D. G., Lane S. R., Myers J., Kephart G. M., Gleich G. J. A clinical and pathologic study of chronic sinusitis: the role of the eosinophil. J Allergy Clin Immunol. 1988 May;81(5 Pt 1):867–875. doi: 10.1016/0091-6749(88)90944-x. [DOI] [PubMed] [Google Scholar]
  21. Henderson W. R., Chi E. Y., Klebanoff S. J. Eosinophil peroxidase-induced mast cell secretion. J Exp Med. 1980 Aug 1;152(2):265–279. doi: 10.1084/jem.152.2.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hoyer L. W. The factor VIII complex: structure and function. Blood. 1981 Jul;58(1):1–13. [PubMed] [Google Scholar]
  23. Hubscher T. Role of the eosinophil in the allergic reactions. II. Release of prostaglandins from human eosinophilic leukocytes. J Immunol. 1975 Apr;114(4):1389–1393. [PubMed] [Google Scholar]
  24. Hällgren R., Bjelle A., Venge P. Eosinophil cationic protein in inflammatory synovial effusions as evidence of eosinophil involvement. Ann Rheum Dis. 1984 Aug;43(4):556–562. doi: 10.1136/ard.43.4.556. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Hällgren R., Colombel J. F., Dahl R., Fredens K., Kruse A., Jacobsen N. O., Venge P., Rambaud J. C. Neutrophil and eosinophil involvement of the small bowel in patients with celiac disease and Crohn's disease: studies on the secretion rate and immunohistochemical localization of granulocyte granule constituents. Am J Med. 1989 Jan;86(1):56–64. doi: 10.1016/0002-9343(89)90230-1. [DOI] [PubMed] [Google Scholar]
  26. Hällgren R., Terent A., Venge P. Eosinophil cationic protein (ECP) in the cerebrospinal fluid. J Neurol Sci. 1983 Jan;58(1):57–71. doi: 10.1016/0022-510x(83)90110-7. [DOI] [PubMed] [Google Scholar]
  27. Jong E. C., Mahmoud A. A., Klebanoff S. J. Peroxidase-mediated toxicity to schistosomula of Schistosoma mansoni. J Immunol. 1981 Feb;126(2):468–471. [PubMed] [Google Scholar]
  28. Khalife J., Capron M., Cesbron J. Y., Tai P. C., Taelman H., Prin L., Capron A. Role of specific IgE antibodies in peroxidase (EPO) release from human eosinophils. J Immunol. 1986 Sep 1;137(5):1659–1664. [PubMed] [Google Scholar]
  29. Kierszenbaum F., Villalta F., Tai P. C. Role of inflammatory cells in Chagas' disease. III. Kinetics of human eosinophil activation upon interaction with parasites (Trypanosoma cruzi). J Immunol. 1986 Jan;136(2):662–666. [PubMed] [Google Scholar]
  30. Lam S., LeRiche J., Phillips D., Chan-Yeung M. Cellular and protein changes in bronchial lavage fluid after late asthmatic reaction in patients with red cedar asthma. J Allergy Clin Immunol. 1987 Jul;80(1):44–50. doi: 10.1016/s0091-6749(87)80189-6. [DOI] [PubMed] [Google Scholar]
  31. Lee T., Lenihan D. J., Malone B., Roddy L. L., Wasserman S. I. Increased biosynthesis of platelet-activating factor in activated human eosinophils. J Biol Chem. 1984 May 10;259(9):5526–5530. [PubMed] [Google Scholar]
  32. Mapp C. E., Boschetto P., Zocca E., Milani G. F., Pivirotto F., Tegazzin V., Fabbri L. M. Pathogenesis of late asthmatic reactions induced by exposure to isocyanates. Bull Eur Physiopathol Respir. 1987 Nov-Dec;23(6):583–586. [PubMed] [Google Scholar]
  33. McLaren D. J., McKean J. R., Olsson I., Venges P., Kay A. B. Morphological studies on the killing of schistosomula of Schistosoma mansoni by human eosinophil and neutrophil cationic proteins in vitro. Parasite Immunol. 1981 Winter;3(4):359–373. doi: 10.1111/j.1365-3024.1981.tb00414.x. [DOI] [PubMed] [Google Scholar]
  34. McLaren D. J., Peterson C. G., Venge P. Schistosoma mansoni: further studies of the interaction between schistosomula and granulocyte-derived cationic proteins in vitro. Parasitology. 1984 Jun;88(Pt 3):491–503. doi: 10.1017/s0031182000054755. [DOI] [PubMed] [Google Scholar]
  35. Olsson I., Venge P. Cationic proteins of human granulocytes. II. Separation of the cationic proteins of the granules of leukemic myeloid cells. Blood. 1974 Aug;44(2):235–246. [PubMed] [Google Scholar]
  36. Olsson I., Venge P., Spitznagel J. K., Lehrer R. I. Arginine-rich cationic proteins of human eosinophil granules: comparison of the constituents of eosinophilic and neutrophilic leukocytes. Lab Invest. 1977 May;36(5):493–500. [PubMed] [Google Scholar]
  37. Olsson I., Venge P. The role of the eosinophil granulocyte in the inflammatory reaction. Allergy. 1979 Dec;34(6):353–367. doi: 10.1111/j.1398-9995.1979.tb02005.x. [DOI] [PubMed] [Google Scholar]
  38. Peterson C. G., Jörnvall H., Venge P. Purification and characterization of eosinophil cationic protein from normal human eosinophils. Eur J Haematol. 1988 May;40(5):415–423. doi: 10.1111/j.1600-0609.1988.tb00850.x. [DOI] [PubMed] [Google Scholar]
  39. Peterson C. G., Skoog V., Venge P. Human eosinophil cationic proteins (ECP and EPX) and their suppressive effects on lymphocyte proliferation. Immunobiology. 1986 Mar;171(1-2):1–13. doi: 10.1016/S0171-2985(86)80013-4. [DOI] [PubMed] [Google Scholar]
  40. Peterson C. G., Venge P. Purification and characterization of a new cationic protein--eosinophil protein-X (EPX)--from granules of human eosinophils. Immunology. 1983 Sep;50(1):19–26. [PMC free article] [PubMed] [Google Scholar]
  41. Rak S., Löwhagen O., Venge P. The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients. J Allergy Clin Immunol. 1988 Sep;82(3 Pt 1):470–480. doi: 10.1016/0091-6749(88)90021-8. [DOI] [PubMed] [Google Scholar]
  42. Shaw R. J., Cromwell O., Kay A. B. Preferential generation of leukotriene C4 by human eosinophils. Clin Exp Immunol. 1984 Jun;56(3):716–722. [PMC free article] [PubMed] [Google Scholar]
  43. Tai P. C., Spry C. J., Peterson C., Venge P., Olsson I. Monoclonal antibodies distinguish between storage and secreted forms of eosinophil cationic protein. Nature. 1984 May 10;309(5964):182–184. doi: 10.1038/309182a0. [DOI] [PubMed] [Google Scholar]
  44. Venge P., Dahl R., Fredens K., Peterson C. G. Epithelial injury by human eosinophils. Am Rev Respir Dis. 1988 Dec;138(6 Pt 2):S54–S57. doi: 10.1164/ajrccm/138.6_Pt_2.S54. [DOI] [PubMed] [Google Scholar]
  45. Venge P., Dahl R., Hällgren R. Enhancement of factor XII dependent reactions by eosinophil cationic protein. Thromb Res. 1979;14(4-5):641–649. doi: 10.1016/0049-3848(79)90119-1. [DOI] [PubMed] [Google Scholar]
  46. Venge P., Dahl R., Peterson C. G. Eosinophil granule proteins in serum after allergen challenge of asthmatic patients and the effects of anti-asthmatic medication. Int Arch Allergy Appl Immunol. 1988;87(3):306–312. doi: 10.1159/000234690. [DOI] [PubMed] [Google Scholar]
  47. Verhagen J., Bruynzeel P. L., Koedam J. A., Wassink G. A., de Boer M., Terpstra G. K., Kreukniet J., Veldink G. A., Vliegenthart J. F. Specific leukotriene formation by purified human eosinophils and neutrophils. FEBS Lett. 1984 Mar 12;168(1):23–28. doi: 10.1016/0014-5793(84)80199-4. [DOI] [PubMed] [Google Scholar]
  48. Wardlaw A. J., Dunnette S., Gleich G. J., Collins J. V., Kay A. B. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis. 1988 Jan;137(1):62–69. doi: 10.1164/ajrccm/137.1.62. [DOI] [PubMed] [Google Scholar]
  49. Wasmoen T. L., Bell M. P., Loegering D. A., Gleich G. J., Prendergast F. G., McKean D. J. Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein. J Biol Chem. 1988 Sep 5;263(25):12559–12563. [PubMed] [Google Scholar]
  50. Weller P. F., Goetzl E. J., Austen K. F. Identification of human eosinophil lysophospholipase as the constituent of Charcot-Leyden crystals. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7440–7443. doi: 10.1073/pnas.77.12.7440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Weller P. F., Goetzl E. J. The regulatory and effector roles of eosinophils. Adv Immunol. 1979;27:339–371. doi: 10.1016/s0065-2776(08)60264-3. [DOI] [PubMed] [Google Scholar]
  52. Winqvist I., Olofsson T., Olsson I. Mechanisms for eosinophil degranulation; release of the eosinophil cationic protein. Immunology. 1984 Jan;51(1):1–8. [PMC free article] [PubMed] [Google Scholar]
  53. Yazdanbakhsh M., Tai P. C., Spry C. J., Gleich G. J., Roos D. Synergism between eosinophil cationic protein and oxygen metabolites in killing of schistosomula of Schistosoma mansoni. J Immunol. 1987 May 15;138(10):3443–3447. [PubMed] [Google Scholar]
  54. Young J. D., Peterson C. G., Venge P., Cohn Z. A. Mechanism of membrane damage mediated by human eosinophil cationic protein. Nature. 1986 Jun 5;321(6070):613–616. doi: 10.1038/321613a0. [DOI] [PubMed] [Google Scholar]

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