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(A) Point-mutations and blunt DSBs target the same residues in the rearranged VHDJH gene segment expressed in human CL-01 B cells. Letters above the VHDJH sequence depict base changes; wedges below the VHDJH sequence indicate positions of DSBs. RGYW/WRCY are highlighted in purple and RGY/RCY in green. (B) Most DSBs in rearranged VHDJH genes target the mutational RGY(W)/WRC(Y) hotspot. DSBs within RGY(W)/WRC(Y) and those outside are 69, 18, and 13%, respectively of the total blunt DSBs.
