Abstract
In a study of 58 patients the concentrations of cefixime, a new oral cephem antibiotic, in bronchial mucosa were 35-40% of the concentrations found in simultaneously collected serum samples. The antibiotic was often undetectable in sputum despite a highly sensitive assay.
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Selected References
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- Bergogne-Berezin E. Penetration of antibiotics into the respiratory tree. J Antimicrob Chemother. 1981 Sep;8(3):171–174. doi: 10.1093/jac/8.3.171. [DOI] [PubMed] [Google Scholar]
- Duguid J. P., Clegg S., Wilson M. I. The fimbrial and non-fimbrial haemagglutinins of Escherichia coli. J Med Microbiol. 1979 May;12(2):213–227. doi: 10.1099/00222615-12-2-213. [DOI] [PubMed] [Google Scholar]
- Honeybourne D., Andrews J. M., Ashby J. P., Lodwick R., Wise R. Evaluation of the penetration of ciprofloxacin and amoxycillin into the bronchial mucosa. Thorax. 1988 Sep;43(9):715–719. doi: 10.1136/thx.43.9.715. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marlin G. E., Burgess K. R., Burgoyne J., Funnell G. R., Guinness M. D. Penetration of piperacillin into bronchial mucosa and sputum. Thorax. 1981 Oct;36(10):774–780. doi: 10.1136/thx.36.10.774. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marlin G. E., Nicholls A. J., Funnell G. R., Bradbury R. Penetration of cefaclor into bronchial mucosa. Thorax. 1984 Nov;39(11):813–817. doi: 10.1136/thx.39.11.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Palmer L. B. Bacterial colonization: pathogenesis and clinical significance. Clin Chest Med. 1987 Sep;8(3):455–466. [PubMed] [Google Scholar]
- Pennington J. E. Penetration of antibiotics into respiratory secretions. Rev Infect Dis. 1981 Jan-Feb;3(1):67–73. doi: 10.1093/clinids/3.1.67. [DOI] [PubMed] [Google Scholar]