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. 1990 Jun;45(6):442–446. doi: 10.1136/thx.45.6.442

Clinical correlates of angiographically diagnosed idiopathic pulmonary hypertension.

H H Gray 1, J M Morgan 1, I H Kerr 1, G A Miller 1
PMCID: PMC462526  PMID: 2392788

Abstract

During 1970-87 43 patients with unexplained pulmonary hypertension (mean pulmonary arterial pressure greater than 25 mm Hg) were admitted to the Brompton Hospital and classified by angiographic criteria as having either symmetrical peripheral pulmonary artery pruning (thought to represent primary plexogenic pulmonary arteriopathy), n = 21, or asymmetrical pulmonary arterial occlusions (thought to represent chronic thromboembolic disease), n = 22. Patients with symmetrical pulmonary arteriopathy had significantly higher mean pulmonary arterial pressures (67 mm Hg) at the time of presentation than those with asymmetrical pulmonary arteriopathy (49 mm Hg). Clinical distinction between these two groups was impossible. Survival from the time of diagnosis was similarly poor in the two groups (26 weeks and 38 weeks) and did not correlate with any of the haemodynamic measurements. The difficulties in making distinctions between these conditions are discussed.

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Selected References

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  1. Anderson G., Reid L., Simon G. The radiographic appearances in primary and in thrombo-embolic pulmonary hypertension. Clin Radiol. 1973 Jan;24(1):113–120. doi: 10.1016/s0009-9260(73)80129-1. [DOI] [PubMed] [Google Scholar]
  2. Bjornsson J., Edwards W. D. Primary pulmonary hypertension: a histopathologic study of 80 cases. Mayo Clin Proc. 1985 Jan;60(1):16–25. doi: 10.1016/s0025-6196(12)65277-x. [DOI] [PubMed] [Google Scholar]
  3. Bomalaski J. S., Martin G. J., Hughes R. L., Yao J. S. Inferior vena cava interruption in the management of pulmonary embolism. Chest. 1982 Dec;82(6):767–774. doi: 10.1378/chest.82.6.767. [DOI] [PubMed] [Google Scholar]
  4. CHRISPIN A. R., GOODWIN J. F., STEINER R. E. THE RADIOLOGY OF OBLITERATIVE PULMONARY HYPERTENSION AND THROMBO-EMBOLISM. Br J Radiol. 1963 Oct;36:705–714. doi: 10.1259/0007-1285-36-430-705. [DOI] [PubMed] [Google Scholar]
  5. Chitwood W. R., Jr, Lyerly H. K., Sabiston D. C., Jr Surgical management of chronic pulmonary embolism. Ann Surg. 1985 Jan;201(1):11–26. [PMC free article] [PubMed] [Google Scholar]
  6. D'Alonzo G. E., Bower J. S., Dantzker D. R. Differentiation of patients with primary and thromboembolic pulmonary hypertension. Chest. 1984 Apr;85(4):457–461. doi: 10.1378/chest.85.4.457. [DOI] [PubMed] [Google Scholar]
  7. Fishman A. J., Moser K. M., Fedullo P. F. Perfusion lung scans vs pulmonary angiography in evaluation of suspected primary pulmonary hypertension. Chest. 1983 Dec;84(6):679–683. doi: 10.1378/chest.84.6.679. [DOI] [PubMed] [Google Scholar]
  8. Fuster V., Steele P. M., Edwards W. D., Gersh B. J., McGoon M. D., Frye R. L. Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation. 1984 Oct;70(4):580–587. doi: 10.1161/01.cir.70.4.580. [DOI] [PubMed] [Google Scholar]
  9. Gray H. H., Morgan J. M., Paneth M., Miller G. A. Pulmonary embolectomy for acute massive pulmonary embolism: an analysis of 71 cases. Br Heart J. 1988 Sep;60(3):196–200. doi: 10.1136/hrt.60.3.196. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Greenfield L. J. Current indications for and results of Greenfield filter placement. J Vasc Surg. 1984 May;1(3):502–504. doi: 10.1067/mva.1984.avs0010502. [DOI] [PubMed] [Google Scholar]
  11. Haissaguerre M., Bonnet J., Douvier J. J., Bricaud H. Comparison of fibrinolytic treatment with interruption of the inferior caval vein in the prevention of pulmonary embolism. Int J Cardiol. 1986 Aug;12(2):213–221. doi: 10.1016/0167-5273(86)90244-5. [DOI] [PubMed] [Google Scholar]
  12. Haworth S. G. Primary pulmonary hypertension. Br Heart J. 1983 Jun;49(6):517–521. doi: 10.1136/hrt.49.6.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hughes J. D., Rubin L. J. Primary pulmonary hypertension. An analysis of 28 cases and a review of the literature. Medicine (Baltimore) 1986 Jan;65(1):56–72. [PubMed] [Google Scholar]
  14. Jones D. K., Higenbottam T. W., Wallwork J. Treatment of primary pulmonary hypertension intravenous epoprostenol (prostacyclin). Br Heart J. 1987 Mar;57(3):270–278. doi: 10.1136/hrt.57.3.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mansour M., Chang A. E., Sindelar W. F. Interruption of the inferior vena cava for the prevention of recurrent pulmonary embolism. Am Surg. 1985 Jul;51(7):375–380. [PubMed] [Google Scholar]
  16. Michael J. R., Summer W. R. Pulmonary hypertension. Lung. 1985;163(2):65–82. doi: 10.1007/BF02713809. [DOI] [PubMed] [Google Scholar]
  17. Mills S. R., Jackson D. C., Older R. A., Heaston D. K., Moore A. V. The incidence, etiologies, and avoidance of complications of pulmonary angiography in a large series. Radiology. 1980 Aug;136(2):295–299. doi: 10.1148/radiology.136.2.7403500. [DOI] [PubMed] [Google Scholar]
  18. Moser K. M., Daily P. O., Peterson K., Dembitsky W., Vapnek J. M., Shure D., Utley J., Archibald C. Thromboendarterectomy for chronic, major-vessel thromboembolic pulmonary hypertension. Immediate and long-term results in 42 patients. Ann Intern Med. 1987 Oct;107(4):560–565. doi: 10.7326/0003-4819-107-4-560. [DOI] [PubMed] [Google Scholar]
  19. Nicod P., Peterson K., Levine M., Dittrich H., Buchbinder M., Chappuis F., Moser K. Pulmonary angiography in severe chronic pulmonary hypertension. Ann Intern Med. 1987 Oct;107(4):565–568. doi: 10.7326/0003-4819-107-4-565. [DOI] [PubMed] [Google Scholar]
  20. Oakley C. M. Management of primary pulmonary hypertension. Br Heart J. 1985 Jan;53(1):1–4. doi: 10.1136/hrt.53.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Rich S., Brundage B. H., Levy P. S. The effect of vasodilator therapy on the clinical outcome of patients with primary pulmonary hypertension. Circulation. 1985 Jun;71(6):1191–1196. doi: 10.1161/01.cir.71.6.1191. [DOI] [PubMed] [Google Scholar]
  22. Rich S., Dantzker D. R., Ayres S. M., Bergofsky E. H., Brundage B. H., Detre K. M., Fishman A. P., Goldring R. M., Groves B. M., Koerner S. K. Primary pulmonary hypertension. A national prospective study. Ann Intern Med. 1987 Aug;107(2):216–223. doi: 10.7326/0003-4819-107-2-216. [DOI] [PubMed] [Google Scholar]
  23. Rich S., Levy P. S. Characteristics of surviving and nonsurviving patients with primary pulmonary hypertension. Am J Med. 1984 Apr;76(4):573–578. doi: 10.1016/0002-9343(84)90279-1. [DOI] [PubMed] [Google Scholar]
  24. Rozkovec A., Montanes P., Oakley C. M. Factors that influence the outcome of primary pulmonary hypertension. Br Heart J. 1986 May;55(5):449–458. doi: 10.1136/hrt.55.5.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Rozkovec A., Stradling J. R., Shepherd G., MacDermot J., Oakley C. M., Dollery C. T. Prediction of favourable responses to long term vasodilator treatment of pulmonary hypertension by short term administration of epoprostenol (prostacyclin) or nifedipine. Br Heart J. 1988 Jun;59(6):696–705. doi: 10.1136/hrt.59.6.696. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Wagenvoort C. A. Lung biopsy specimens in the evaluation of pulmonary vascular disease. Chest. 1980 May;77(5):614–625. doi: 10.1378/chest.77.5.614. [DOI] [PubMed] [Google Scholar]
  27. Wilson A. G., Harris C. N., Lavender J. P., Oakley C. M. Perfusion lung scanning in obliterative pulmonary hypertension. Br Heart J. 1973 Sep;35(9):917–930. doi: 10.1136/hrt.35.9.917. [DOI] [PMC free article] [PubMed] [Google Scholar]

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