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. 1990 Jul;45(7):530–535. doi: 10.1136/thx.45.7.530

Effect on histamine responsiveness of reducing airway dimensions by altering posture.

Y T Wang 1, C I Coe 1, N B Pride 1
PMCID: PMC462583  PMID: 2396233

Abstract

Baseline airway geometry is thought to be an important determinant of the airway response to challenge; this geometry is altered by changing posture. The effect of changes in posture on airway calibre, midtidal lung volume, and the airway response to inhaled histamine was studied in eight healthy subjects (four female; mean (SD) age 29.8 (5.1) years, FEV1 3.54 (0.65) 1). Each subject was studied in both sitting and supine postures on two days; airway calibre was assessed by measuring total respiratory resistance (Rrs) at 6 Hz with a forced oscillation technique applied over 16 seconds of tidal breathing. Appropriate doses of histamine were selected by preliminary experiments and were always inhaled with the subject in the supine posture. Midtidal lung volume was larger in the sitting (2.9 (0.8) 1) than in the supine posture (2.4 (0.5) 1). Baseline Rrs was lower in the sitting than in the supine posture (2.03 (0.44) and 3.12 (0.76) cm H2O.1(-1).s*). The mean absolute increase in Rrs after the same dose of histamine was 1.22 cm H2O.1(-1).s in the sitting position (65.8% increase over baseline) and 1.39 cm H2O.1(-1).s (48.8% increase over baseline) in the supine position. The geometric mean provocation concentration of histamine causing a given percentage increase in Rrs was similar in the sitting (8.26 mg/ml) and supine (8.65 mg/ml) positions. Thus there was no significant increase in responsiveness after the reduction of airway dimensions and extra-airway distending forces that occurs in the supine posture.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOUHUYS A. Effect of posture in experimental asthma in man. Am J Med. 1963 Apr;34:470–476. doi: 10.1016/0002-9343(63)90069-x. [DOI] [PubMed] [Google Scholar]
  2. Behrakis P. K., Baydur A., Jaeger M. J., Milic-Emili J. Lung mechanics in sitting and horizontal body positions. Chest. 1983 Apr;83(4):643–646. doi: 10.1378/chest.83.4.643. [DOI] [PubMed] [Google Scholar]
  3. Chinet T., Pelle G., Macquin-Mavier I., Lorino H., Harf A. Comparison of the dose-response curves obtained by forced oscillation and plethysmography during carbachol inhalation. Eur Respir J. 1988 Jul;1(7):600–605. [PubMed] [Google Scholar]
  4. DUBOIS A. B., BOTELHO S. Y., BEDELL G. N., MARSHALL R., COMROE J. H., Jr A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. J Clin Invest. 1956 Mar;35(3):322–326. doi: 10.1172/JCI103281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ding D. J., Martin J. G., Macklem P. T. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Physiol (1985) 1987 Mar;62(3):1324–1330. doi: 10.1152/jappl.1987.62.3.1324. [DOI] [PubMed] [Google Scholar]
  7. Freedman B. J. The functional geometry of the bronchi. The relationship between changes in external diameter and calibre, and a consideration of the passive role played by the mucosa in bronchoconstriction. Bull Physiopathol Respir (Nancy) 1972 May-Jun;8(3):545–552. [PubMed] [Google Scholar]
  8. James A. L., Paré P. D., Hogg J. C. The mechanics of airway narrowing in asthma. Am Rev Respir Dis. 1989 Jan;139(1):242–246. doi: 10.1164/ajrccm/139.1.242. [DOI] [PubMed] [Google Scholar]
  9. Jönsson E., Mossberg B. Impairment of ventilatory function by supine posture in asthma. Eur J Respir Dis. 1984 Oct;65(7):496–503. [PubMed] [Google Scholar]
  10. Lándsér F. J., Nagles J., Demedts M., Billiet L., van de Woestijne K. P. A new method to determine frequency characteristics of the respiratory system. J Appl Physiol. 1976 Jul;41(1):101–106. doi: 10.1152/jappl.1976.41.1.101. [DOI] [PubMed] [Google Scholar]
  11. Manning P. J., Jones G. L., O'Byrne P. M. Tachyphylaxis to inhaled histamine in asthmatic subjects. J Appl Physiol (1985) 1987 Oct;63(4):1572–1577. doi: 10.1152/jappl.1987.63.4.1572. [DOI] [PubMed] [Google Scholar]
  12. Mead J., Takishima T., Leith D. Stress distribution in lungs: a model of pulmonary elasticity. J Appl Physiol. 1970 May;28(5):596–608. doi: 10.1152/jappl.1970.28.5.596. [DOI] [PubMed] [Google Scholar]
  13. Nagels J., Làndsér F. J., van der Linden L., Clément J., Van de Woestijne K. P. Mechanical properties of lungs and chest wall during spontaneous breathing. J Appl Physiol Respir Environ Exerc Physiol. 1980 Sep;49(3):408–416. doi: 10.1152/jappl.1980.49.3.408. [DOI] [PubMed] [Google Scholar]
  14. Navajas D., Farre R., Rotger M. M., Milic-Emili J., Sanchis J. Effect of body posture on respiratory impedance. J Appl Physiol (1985) 1988 Jan;64(1):194–199. doi: 10.1152/jappl.1988.64.1.194. [DOI] [PubMed] [Google Scholar]
  15. Rodenstein D. O., Stănescu D. C. Soft palate and oronasal breathing in humans. J Appl Physiol Respir Environ Exerc Physiol. 1984 Sep;57(3):651–657. doi: 10.1152/jappl.1984.57.3.651. [DOI] [PubMed] [Google Scholar]
  16. SVANBERG L. Influence of posture on the lung volumes, ventilation and circulation in normals; a spirometric-bronchospirometric investigation. Scand J Clin Lab Invest. 1957;9 (Suppl 25):1–195. [PubMed] [Google Scholar]
  17. TENNEY S. M. Fluid volume redistribution and thoracic volume changes during recumbency. J Appl Physiol. 1959 Jan;14(1):129–132. doi: 10.1152/jappl.1959.14.1.129. [DOI] [PubMed] [Google Scholar]
  18. de VRIES, GOEI J. T., BOOY-NOORD H., ORIE N. G. Changes during 24 hours in the lung function and histamine hyperreactivity of the bronchial tree in asthmatic and bronchitic patients. Int Arch Allergy Appl Immunol. 1962;20:93–101. doi: 10.1159/000229248. [DOI] [PubMed] [Google Scholar]

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