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. 1990 Aug;45(8):630–632. doi: 10.1136/thx.45.8.630

Effect of caffeine on histamine bronchoprovocation in asthma.

A Colacone 1, L Bertolo 1, N Wolkove 1, C Cohen 1, H Kreisman 1
PMCID: PMC462648  PMID: 2205947

Abstract

It was recently reported that caffeine may reduce the clinical symptoms of asthma and may prevent the clinical manifestations of this disease. The effect of caffeine on histamine responsiveness is unknown. The effect of caffeine (5 mg/kg) and placebo on histamine responsiveness (the provocation concentration causing a 20% fall in FEV1, PC20) was studied in 10 subjects with mild asthma (prechallenge FEV1 84% of predicted value). The PC20 for histamine bronchoprovocation after caffeine ingestion was 2.65 (95% confidence limits 0.99, 7.10) mg/ml. After placebo the PC20 was 1.89 (0.96, 3.71) mg/ml. It is concluded that caffeine in a dose equivalent to about three cups of coffee has a very small effect, if any, on histamine bronchoprovocation in those with mild asthma. Specific instructions about not having drinks containing caffeine before histamine challenge are therefore not necessary.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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