Figure 1. CFZ (A) effectively decreases the survival of cancer cells (B) and induces apoptosis (C and D).

A, Chemical structure of CFZ. B, The indicated cancer cell lines were treated with different concentrations of CFZ for 24 or 72 h and then subjected to estimation of cell number with the SRB assay. The data are means ± SDs of four replicate determinations. C and D, The indicated cell lines were treated with the given concentrations of CFZ for 24 h and then subjected to preparation of whole-cell protein lysates and subsequent Western blot analysis (C) or ELISA assay to detect DNA fragments (D). The data are means ± SDs of triplicate determinations. CF, cleaved fragment; LE, long exposure.