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. 1990 Dec;45(12):951–956. doi: 10.1136/thx.45.12.951

Performance and prognosis in patients with lung cancer. The Edinburgh Lung Cancer Group.

S Capewell, M F Sudlow
PMCID: PMC462845  PMID: 2177921

Abstract

The Edinburgh Lung Cancer Group prospectively registered 651 new patients presenting with lung cancer during 1981; only 47 survived five years (7%). The survival rate was highest in patients selected for surgery (35/116, 30%) and in this group was related to cell type, stage of disease, and possibly to Karnofsky performance score (not statistically significant). By comparison with non-surgical patients these 116 patients undergoing surgery were highly selected in terms of age, favourable histological type, stage of disease, and performance score. Forty-two of the 535 non-surgical patients were given radical radiotherapy alone and seven (17%) survived five years. The remaining 493 received palliative radiotherapy, chemotherapy (alone or combined with radiotherapy), or symptomatic treatment alone; only five (1%) survived five years. Median survival was related to cell type (adenocarcinoma 2.6 months, squamous cell carcinoma 6.2 months), stage (stage I 8.5 months, stage III 4 months), and Karnofsky performance index (greater than or equal to 90 9.3 months, less than or equal to 50 1.2 months). Age and sex had no independent prognostic value in any group. Performance score was highly correlated with stage (and age) and in this study represented the "best prognostic factor" in clinical practice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aaronson N. K., Bullinger M., Ahmedzai S. A modular approach to quality-of-life assessment in cancer clinical trials. Recent Results Cancer Res. 1988;111:231–249. doi: 10.1007/978-3-642-83419-6_27. [DOI] [PubMed] [Google Scholar]
  2. Aisner J., Alberto P., Bitran J., Comis R., Daniels J., Hansen H., Ikegami H., Smyth J. Role of chemotherapy in small cell lung cancer: a consensus report of the International Association for the Study of Lung Cancer workshop. Cancer Treat Rep. 1983 Jan;67(1):37–43. [PubMed] [Google Scholar]
  3. Belcher J. R. Thirty years of surgery for carcinoma of the bronchus. Thorax. 1983 Jun;38(6):428–432. doi: 10.1136/thx.38.6.428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bignall J. R., Martin M. Survival experience of women with bronchial carcinoma. Lancet. 1972 Jul 8;2(7767):60–62. doi: 10.1016/s0140-6736(72)91551-6. [DOI] [PubMed] [Google Scholar]
  5. Cerny T., Blair V., Anderson H., Bramwell V., Thatcher N. Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients. Int J Cancer. 1987 Feb 15;39(2):146–149. doi: 10.1002/ijc.2910390204. [DOI] [PubMed] [Google Scholar]
  6. Clee M. D., Hockings N. F., Johnston R. N. Bronchial carcinoma: factors influencing postoperative survival. Br J Dis Chest. 1984 Jul;78(3):225–235. [PubMed] [Google Scholar]
  7. Cox J. D., Komaki R., Eierst D. R. Irradiation for inoperable carcinoma of the lung and high performance status. JAMA. 1980 Oct 24;244(17):1931–1933. [PubMed] [Google Scholar]
  8. Finkelstein D. M., Ettinger D. S., Ruckdeschel J. C. Long-term survivors in metastatic non-small-cell lung cancer: an Eastern Cooperative Oncology Group Study. J Clin Oncol. 1986 May;4(5):702–709. doi: 10.1200/JCO.1986.4.5.702. [DOI] [PubMed] [Google Scholar]
  9. Freise G., Gabler A., Liebig S. Bronchial carcinoma and long-term survival. Retrospective study of 433 patients who underwent resection. Thorax. 1978 Apr;33(2):228–234. doi: 10.1136/thx.33.2.228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Geddes D. M. The natural history of lung cancer: a review based on rates of tumour growth. Br J Dis Chest. 1979 Jan;73(1):1–17. [PubMed] [Google Scholar]
  11. Gee J. B., Fick R. B., Jr Bronchoalveolar lavage. Thorax. 1980 Jan;35(1):1–8. doi: 10.1136/thx.35.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gislason T., Nõu E. Sedimentation rate, leucocytes, platelet count and haemoglobin in bronchial carcinoma: an epidemiological study. Eur J Respir Dis. 1985 Feb;66(2):141–146. [PubMed] [Google Scholar]
  13. Hansen H. H. Chemotherapy of small cell carcinoma: a review. Q J Med. 1987 Apr;63(240):275–282. [PubMed] [Google Scholar]
  14. Hyde L., Wolf J., McCracken S., Yesner R. Natural course of inoperable lung cancer. Chest. 1973 Sep;64(3):309–312. doi: 10.1378/chest.64.3.309. [DOI] [PubMed] [Google Scholar]
  15. Johnston R. N., Smith D. H. Symptoms and survival in lung cancer. Lancet. 1971 Nov 20;2(7734):1152–1152. doi: 10.1016/s0140-6736(71)91308-0. [DOI] [PubMed] [Google Scholar]
  16. Jones J. S. Answering the relatives of lung cancer patients. Br J Dis Chest. 1984 Oct;78(4):388–391. doi: 10.1016/s0007-0971(84)80154-0. [DOI] [PubMed] [Google Scholar]
  17. Lamb D. Histological classification of lung cancer. Thorax. 1984 Mar;39(3):161–165. doi: 10.1136/thx.39.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Laszlo J., Lenhard R., Dahlberg S., Feigl P. A profile of treatment approaches used at comprehensive cancer centers. J Chronic Dis. 1982;35(11):853–859. doi: 10.1016/0021-9681(82)90050-9. [DOI] [PubMed] [Google Scholar]
  19. Mould R. F., Williams R. J. Survival of histologically proven carcinoma of the lung registered in the North West Thames Region, 1975-1979. Br J Cancer. 1982 Dec;46(6):999–1003. doi: 10.1038/bjc.1982.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Mountain C. F. Assessment of the role of surgery for control of lung cancer. Ann Thorac Surg. 1977 Oct;24(4):365–373. doi: 10.1016/s0003-4975(10)63416-9. [DOI] [PubMed] [Google Scholar]
  21. Osterlind K., Andersen P. K. Prognostic factors in small cell lung cancer: multivariate model based on 778 patients treated with chemotherapy with or without irradiation. Cancer Res. 1986 Aug;46(8):4189–4194. [PubMed] [Google Scholar]
  22. Pastorino U., Valente M., Bedini V., Pagnoni A., Ravasi G. Effect of chronic cardiopulmonary disease on survival after resection for stage Ia lung cancer. Thorax. 1982 Sep;37(9):680–683. doi: 10.1136/thx.37.9.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Rossing T. H., Rossing R. G. Survival in lung cancer. An analysis of the effects of age, sex, resectability, and histopathologic type. Am Rev Respir Dis. 1982 Nov;126(5):771–777. doi: 10.1164/arrd.1982.126.5.771. [DOI] [PubMed] [Google Scholar]
  24. Smyth J. F., Fowlie S. M., Gregor A., Crompton G. K., Busuttil A., Leonard R. C., Grant I. W. The impact of chemotherapy on small cell carcinoma of the bronchus. Q J Med. 1986 Oct;61(234):969–976. [PubMed] [Google Scholar]
  25. Soorae A. S., Smith R. A. Tumour size as a prognostic factor after resection of lung carcinoma. Thorax. 1977 Feb;32(1):19–25. doi: 10.1136/thx.32.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Souhami R. L., Bradbury I., Geddes D. M., Spiro S. G., Harper P. G., Tobias J. S. Prognostic significance of laboratory parameters measured at diagnosis in small cell carcinoma of the lung. Cancer Res. 1985 Jun;45(6):2878–2882. [PubMed] [Google Scholar]
  27. Spiro S., Goldstraw P. The staging of lung cancer. Thorax. 1984 Jun;39(6):401–407. doi: 10.1136/thx.39.6.401. [DOI] [PMC free article] [PubMed] [Google Scholar]

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