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. 1991 Mar;46(3):180–183. doi: 10.1136/thx.46.3.180

Lung function in primary Sjögren's syndrome: a cross sectional and longitudinal study.

C Kelly 1, P Gardiner 1, B Pal 1, I Griffiths 1
PMCID: PMC463025  PMID: 2028432

Abstract

Clinical and radiological assessment of 100 patients (97 female) with primary Sjögren's syndrome was performed within six months of diagnosis in conjunction with spirometry and measurement of transfer factor for carbon monoxide (TLCO). This was repeated in an unselected subgroup of 30 patients after a mean interval of four years. On initial assessment, 43 patients had symptoms of lung disease and 10 had related physical signs; the chest radiograph was abnormal in five. There was a significant reduction (more than 2 standardised residuals) in forced expiratory volume in one second (FEV1), vital capacity (VC), and TLCO in 14, 12, and 10 patients, 24 patients overall having a significant reduction in one or more of these measures. There was a strong relation between reduction in lung function and both pulmonary symptoms and a lip biopsy specimen positive for Sjögren's syndrome. Lung function at the initial assessment in the 30 patients who were restudied was almost identical to that of the group as a whole. Seventeen now had symptoms and nine had related physical signs. The chest radiograph was abnormal in four patients. More patients had a significant reduction in FEV1, VC, and TLCO. Lung disease is sometimes an early feature of primary Sjögren's syndrome and may progress over a relatively short period.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUCHER U. G., REID L. Sjogren's syndrome: report of a fatal case with pulmonary and renal lesions. Br J Dis Chest. 1959 Jul;53:237–252. doi: 10.1016/s0007-0971(59)80054-1. [DOI] [PubMed] [Google Scholar]
  2. Constantopoulos S. H., Drosos A. A., Maddison P. J., Moutsopoulos H. M. Xerotrachea and interstitial lung disease in primary Sjogren's syndrome. Respiration. 1984;46(3):310–314. doi: 10.1159/000194703. [DOI] [PubMed] [Google Scholar]
  3. Fox R. I., Robinson C. A., Curd J. G., Kozin F., Howell F. V. Sjögren's syndrome. Proposed criteria for classification. Arthritis Rheum. 1986 May;29(5):577–585. doi: 10.1002/art.1780290501. [DOI] [PubMed] [Google Scholar]
  4. Greenspan J. S., Daniels T. E., Talal N., Sylvester R. A. The histopathology of Sjögren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 1974 Feb;37(2):217–229. doi: 10.1016/0030-4220(74)90417-4. [DOI] [PubMed] [Google Scholar]
  5. Hansen L. A., Prakash U. B., Colby T. V. Pulmonary lymphoma in Sjögren's syndrome. Mayo Clin Proc. 1989 Aug;64(8):920–931. doi: 10.1016/s0025-6196(12)61219-1. [DOI] [PubMed] [Google Scholar]
  6. Hatron P. Y., Wallaert B., Gosset D., Tonnel A. B., Gosselin B., Voisin C., Devulder B. Subclinical lung inflammation in primary Sjögren's syndrome. Relationship between bronchoalveolar lavage cellular analysis findings and characteristics of the disease. Arthritis Rheum. 1987 Nov;30(11):1226–1231. doi: 10.1002/art.1780301104. [DOI] [PubMed] [Google Scholar]
  7. Hedgpeth M. T., Boulware D. W. Pulmonary hypertension in primary Sjögren's syndrome. Ann Rheum Dis. 1988 Mar;47(3):251–253. doi: 10.1136/ard.47.3.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kamholz S., Sher A., Barland P., Rosen N., Rakoff S., Becker N. Sjögren's syndrome: severe upper airways obstruction due to primary malignant tracheal lymphoma developing during successful treatment of lymphocytic interstitial pneumonitis. J Rheumatol. 1987 Jun;14(3):588–594. [PubMed] [Google Scholar]
  9. Miller M. R., Pincock A. C. Predicted values: how should we use them? Thorax. 1988 Apr;43(4):265–267. doi: 10.1136/thx.43.4.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Newball H. H., Brahim S. A. Chronic obstructive airway disease in patients with Sjögren's syndrome. Am Rev Respir Dis. 1977 Feb;115(2):295–304. doi: 10.1164/arrd.1977.115.2.295. [DOI] [PubMed] [Google Scholar]
  11. Oxholm P., Bundgaard A., Birk Madsen E., Manthorpe R., Vejlø Rasmussen F. Pulmonary function in patients with primary Sjögren's syndrome. Rheumatol Int. 1982;2(4):179–181. doi: 10.1007/BF00286141. [DOI] [PubMed] [Google Scholar]
  12. Segal I., Fink G., Machtey I., Gura V., Spitzer S. A. Pulmonary function abnormalities in Sjögren's syndrome and the sicca complex. Thorax. 1981 Apr;36(4):286–289. doi: 10.1136/thx.36.4.286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Strimlan C. V., Rosenow E. C., 3rd, Divertie M. B., Harrison E. G., Jr Pulmonary manifestations of Sjögren's syndrome. Chest. 1976 Sep;70(03):354–361. doi: 10.1378/chest.70.3.354. [DOI] [PubMed] [Google Scholar]
  14. Strimlan C. V., Rosenow E. C., 3rd, Weiland L. H., Brown L. R. Lymphocytic interstitial pneumonitis. Review of 13 cases. Ann Intern Med. 1978 May;88(5):616–621. doi: 10.7326/0003-4819-88-5-616. [DOI] [PubMed] [Google Scholar]
  15. TALAL N., BUNIM J. J. THE DEVELOPMENT OF MALIGNANT LYMPHOMA IN THE COURSE OF SJOEGREN'S SYNDROME. Am J Med. 1964 Apr;36:529–540. doi: 10.1016/0002-9343(64)90101-9. [DOI] [PubMed] [Google Scholar]
  16. Venables P. J., Charles P. J., Buchanan R. R., Yi T., Mumford P. A., Schrieber L., Room G. R., Maini R. N. Quantitation and detection of isotypes of anti-SS-B antibodies by ELISA and Farr assays using affinity purified antigens. An approach to the investigation of Sjögren's syndrome and systemic lupus erythematosus. Arthritis Rheum. 1983 Feb;26(2):146–155. doi: 10.1002/art.1780260205. [DOI] [PubMed] [Google Scholar]
  17. Vitali C., Tavoni A., Viegi G., Begliomini E., Agnesi A., Bombardieri S. Lung involvement in Sjögren's syndrome: a comparison between patients with primary and with secondary syndrome. Ann Rheum Dis. 1985 Jul;44(7):455–461. doi: 10.1136/ard.44.7.455. [DOI] [PMC free article] [PubMed] [Google Scholar]

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