Table 4. Pragmatic DEG call methods for four combinations of biological effect size and replicate size, with suggested applications.

	Biological effect size
Replicate size	Mild	Strong
1	Nothing works	GFOLDv, NOISeqv
3+	GFOLDv, NOISeqv	GFOLDv, DESeq2s, edgeRs

Notes.

v

for validation work

s

for systems biology work