Volume 301, November 2011
Foster MW, Yang Z, Potts EN, Foster WM, Que LG. S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction. Am J Physiol Lung Cell Mol Physiol 301: L739–L744, 2011; doi: 10.1152/ajplung.00134.2011.
After publication the authors became aware that the primary data used to calculate the in vivo pulmonary mechanics results were inconsistent with the flexiVent machine-generated raw data, making the data presented in Figs. 1B, 1C, 2B, and 2C unreliable. Moreover, multiplex data presented in Fig. 4 did not match machine-generated raw data, making this data also unreliable.
One of the main experiments, presented in Fig. 2B, was repeated; while the authors found that aerosolized GSNO (10 mM) reduces total airway resistance, it was not significant to the degree demonstrated in the article.
The authors are confident that the other data (Figs. 1A, 2D, 2A, 2D, 3) remain valid. However, since the main finding has not been reproduced by Drs. Que, M. W. Foster, Yang, and W. M. Foster's additional work, the authors have requested retraction of the publication. The authors apologize to the scientific community for any loss of time and resources caused by this publication.