Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1991 Jun;46(6):433–437. doi: 10.1136/thx.46.6.433

Use of transcutaneous oxygen tension, arterial oxygen saturation, and respiratory resistance to assess the response to inhaled methacholine in asthmatic children and normal adults.

N M Wilson 1, S B Phagoo 1, M Silverman 1
PMCID: PMC463191  PMID: 1858082

Abstract

Respiratory resistance (Rrs6), transcutaneous oxygen tension (PtcO2), and oxygen saturation (SaO2) were measured during methacholine challenge in 15 asthmatic children and six normal adults. During bronchoconstriction, induced by a wide range of inhaled methacholine concentrations (0.5-256 g/l), the rise in Rrs6 was reflected by a fall in PtcO2 in all subjects. Although there was a significant mean fall in SaO2 at maximum bronchoconstriction there was no consistent relation between changes in SaO2 and Rrs6. The inhaled dose of methacholine causing a 40% increase in Rrs6 (PD40Rrs6) and a 20% fall in PtCO2 (PD20PtcO2) was calculated for each subject. There was no significant difference in mean PD40Rrs6 and PD20PtcO2, and the relation between the two was similar in the asthmatic children and the normal adults. It was therefore concluded that the measurement of PtcO2, but not SaO2, during methacholine challenge can be used for the assessment of bronchial responsiveness, and that it could prove particularly useful for children too young to cooperate with lung function tests.

Full text

PDF
433

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Buhr W., Jörres R., Berdel D., Làndsér F. J. Correspondence between forced oscillation and body plethysmography during bronchoprovocation with carbachol in children. Pediatr Pulmonol. 1990;8(4):280–288. doi: 10.1002/ppul.1950080413. [DOI] [PubMed] [Google Scholar]
  2. Dal Negro R., Allegra L. Blood gas changes during and after nonspecific airway challenge in asthmatic and normal subjects. J Appl Physiol (1985) 1989 Dec;67(6):2627–2630. doi: 10.1152/jappl.1989.67.6.2627. [DOI] [PubMed] [Google Scholar]
  3. Duiverman E. J., Clément J., van de Woestijne K. P., Neijens H. J., van den Bergh A. C., Kerrebijn K. F. Forced oscillation technique. Reference values for resistance and reactance over a frequency spectrum of 2-26 Hz in healthy children aged 2.3-12.5 years. Bull Eur Physiopathol Respir. 1985 Mar-Apr;21(2):171–178. [PubMed] [Google Scholar]
  4. Duiverman E. J., Neijens H. J., Van der Snee-van Smaalen M., Kerrebijn K. F. Comparison of forced oscillometry and forced expirations for measuring dose-related responses to inhaled methacholine in asthmatic children. Bull Eur Physiopathol Respir. 1986 Sep-Oct;22(5):433–436. [PubMed] [Google Scholar]
  5. Hedlin G., Freyschuss U., Hedenstierna G. Histamine-induced asthma in children: effects on the ventilation-perfusion relationship. Clin Physiol. 1985 Feb;5(1):19–34. doi: 10.1111/j.1475-097x.1985.tb00743.x. [DOI] [PubMed] [Google Scholar]
  6. Lándsér F. J., Nagles J., Demedts M., Billiet L., van de Woestijne K. P. A new method to determine frequency characteristics of the respiratory system. J Appl Physiol. 1976 Jul;41(1):101–106. doi: 10.1152/jappl.1976.41.1.101. [DOI] [PubMed] [Google Scholar]
  7. Mochizuki H., Mitsuhashi M., Tokuyama K., Tajima K., Morikawa A., Kuroume T. A new method of estimating bronchial hyper-responsiveness in younger children. Ann Allergy. 1985 Aug;55(2):162–166. [PubMed] [Google Scholar]
  8. Pradal U., Braggion C., Mastella G. Transcutaneous blood gas analysis during sleep and exercise in cystic fibrosis. Pediatr Pulmonol. 1990;8(3):162–167. doi: 10.1002/ppul.1950080306. [DOI] [PubMed] [Google Scholar]
  9. Prendiville A., Rose A., Maxwell D. L., Silverman M. Hypoxaemia in wheezy infants after bronchodilator treatment. Arch Dis Child. 1987 Oct;62(10):997–1000. doi: 10.1136/adc.62.10.997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Rodriguez-Roisin R., Wagner P. D. Clinical relevance of ventilation-perfusion inequality determined by inert gas elimination. Eur Respir J. 1990 Apr;3(4):469–482. [PubMed] [Google Scholar]
  11. Solymar L., Aronsson P. H., Bake B., Bjure J. Respiratory resistance and impedance magnitude in healthy children aged 2-18 years. Pediatr Pulmonol. 1985 May-Jun;1(3):134–140. doi: 10.1002/ppul.1950010303. [DOI] [PubMed] [Google Scholar]
  12. Stewart I. C., Parker A., Catterall J. R., Douglas N. J., Flenley D. C. Effect of bronchial challenge on breathing patterns and arterial oxygenation in stable asthma. Chest. 1989 Jan;95(1):65–70. doi: 10.1378/chest.95.1.65. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES