Fig. 1.

The GBM patient cohort: Molecular diversity and correlations between establishment of GC lines, survival and age. (A) Kaplan–Meier comparison of the survival of patients with GBM from whom sustainable cell lines could (solid line) and could not (dotted line) be established. Log-rank test, *p < 0.05. (B) Kaplan–Meier comparison of survival versus age. The oldest patients (71–82 years old, average 74) are above the third quartile, the intermediate ones (57–70, average 64) between first and third quartiles, and the youngest (21–56 years old, average 48) below the first quartile. Log-rank test, **p < 0.01. (C) Age distribution of the patients from whom a sustainable GC line could (average age 66 years) and could not (average age 59 years) be established. Student's t-test, **p < 0.01. (D) Isomap analysis of 48 GC lines and 529 TCGA tissue samples of known molecular subtypes.