Abstract
Myxococcus xanthus, one of the simplest of multicellular organisms, develops into an organized, multicellular aggregate, called a fruiting body. Examination of the internal structure of the nascent fruiting body showed it to consist of a hemispherical outer domain of densely packed and ordered cells. Inside this dense shell is an inner domain of less ordered cells at 3-fold lower cell density. Single cells move in a bidirectional stream in the outer domain, orbiting the fruiting body throughout development, whereas in the inner domain, cell movement ceases as the fruiting body matures. The fruiting body thus consists of two domains, distinguished from each other by differential cell density, cell arrangements, and cell movements.
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Selected References
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- Blackhart B. D., Zusman D. R. "Frizzy" genes of Myxococcus xanthus are involved in control of frequency of reversal of gliding motility. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8767–8770. doi: 10.1073/pnas.82.24.8767. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brakenhoff G. J., van der Voort H. T., van Spronsen E. A., Nanninga N. Three-dimensional imaging in fluorescence by confocal scanning microscopy. J Microsc. 1989 Feb;153(Pt 2):151–159. doi: 10.1111/j.1365-2818.1989.tb00555.x. [DOI] [PubMed] [Google Scholar]
- Devreotes P. Dictyostelium discoideum: a model system for cell-cell interactions in development. Science. 1989 Sep 8;245(4922):1054–1058. doi: 10.1126/science.2672337. [DOI] [PubMed] [Google Scholar]
- Durston A. J. Pacemaker activity during aggregation in Dictyostelium discoideum. Dev Biol. 1974 Apr;37(2):225–235. doi: 10.1016/0012-1606(74)90144-4. [DOI] [PubMed] [Google Scholar]
- Horan P. K., Slezak S. E. Stable cell membrane labelling. Nature. 1989 Jul 13;340(6229):167–168. doi: 10.1038/340167a0. [DOI] [PubMed] [Google Scholar]
- Kaiser D., Kroos L., Kuspa A. Cell interactions govern the temporal pattern of Myxococcus development. Cold Spring Harb Symp Quant Biol. 1985;50:823–830. doi: 10.1101/sqb.1985.050.01.100. [DOI] [PubMed] [Google Scholar]
- Kaiser D. Social gliding is correlated with the presence of pili in Myxococcus xanthus. Proc Natl Acad Sci U S A. 1979 Nov;76(11):5952–5956. doi: 10.1073/pnas.76.11.5952. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kim S. K., Kaiser D. C-factor: a cell-cell signaling protein required for fruiting body morphogenesis of M. xanthus. Cell. 1990 Apr 6;61(1):19–26. doi: 10.1016/0092-8674(90)90211-v. [DOI] [PubMed] [Google Scholar]
- Kim S. K., Kaiser D. Cell alignment required in differentiation of Myxococcus xanthus. Science. 1990 Aug 24;249(4971):926–928. doi: 10.1126/science.2118274. [DOI] [PubMed] [Google Scholar]
- Kroos L., Kuspa A., Kaiser D. A global analysis of developmentally regulated genes in Myxococcus xanthus. Dev Biol. 1986 Sep;117(1):252–266. doi: 10.1016/0012-1606(86)90368-4. [DOI] [PubMed] [Google Scholar]
- LaRossa R., Kuner J., Hagen D., Manoil C., Kaiser D. Developmental cell interactions of Myxococcus xanthus: analysis of mutants. J Bacteriol. 1983 Mar;153(3):1394–1404. doi: 10.1128/jb.153.3.1394-1404.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Connor K. A., Zusman D. R. Patterns of cellular interactions during fruiting-body formation in Myxococcus xanthus. J Bacteriol. 1989 Nov;171(11):6013–6024. doi: 10.1128/jb.171.11.6013-6024.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shimkets L. J., Rafiee H. CsgA, an extracellular protein essential for Myxococcus xanthus development. J Bacteriol. 1990 Sep;172(9):5299–5306. doi: 10.1128/jb.172.9.5299-5306.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shimkets L. J. Social and developmental biology of the myxobacteria. Microbiol Rev. 1990 Dec;54(4):473–501. doi: 10.1128/mr.54.4.473-501.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Siegert F., Weijer C. J. Three-dimensional scroll waves organize Dictyostelium slugs. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6433–6437. doi: 10.1073/pnas.89.14.6433. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stryer L., Haugland R. P. Energy transfer: a spectroscopic ruler. Proc Natl Acad Sci U S A. 1967 Aug;58(2):719–726. doi: 10.1073/pnas.58.2.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tomchik K. J., Devreotes P. N. Adenosine 3',5'-monophosphate waves in Dictyostelium discoideum: a demonstration by isotope dilution--fluorography. Science. 1981 Apr 24;212(4493):443–446. doi: 10.1126/science.6259734. [DOI] [PubMed] [Google Scholar]