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. 1992 Apr;47(4):298–300. doi: 10.1136/thx.47.4.298

Effect of temazepam on tracheobronchial mucus clearance.

A Hasani 1, M A Spiteri 1, D Pavia 1, M T Lopez-Vidriero 1, J E Agnew 1, S W Clarke 1
PMCID: PMC463704  PMID: 1585296

Abstract

BACKGROUND: Tracheobronchial clearance of mucus from the lungs is reduced during sleep and, usually, by the administration of opiates. It seemed possible therefore that temazepam, a widely used potent benzodiazepine, retarded clearance. METHODS: The effect of 10 mg temazepam on mucociliary clearance was studied in eight healthy volunteers, aged 18-50 (mean 30) years, in a randomised, placebo controlled, double blind, cross-over study. Six subjects were female and two male. Six were non-smokers and two were light current smokers. Clearance was assessed from the change in radio-activity in the lungs after inhalation of 5 microns diameter polystyrene particles, labelled with technetium-99m, under controlled conditions. RESULTS: Tracheobronchial clearance was reduced by 22% after temazepam by comparison with placebo during the first three hours after drug ingestion; this is the period when circulating drug concentrations are highest. CONCLUSION: Temazepam should be prescribed with caution in patients with impaired lung mucociliary transport.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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