Table 3.

Effect of statins on aldosterone and cortisol levels in repeated measures analysis adjusted by confounders in hypertensive subjects.

Adrenal hormones 1122 observations	Model 1*		Model 2†
	Statin effect:β (Predicted change)	p value	Statin effect:β (Predicted change)	p value
Aldosterone ng/dl (HSb, HSstim, LSb, LSstim)‡	−4.61 (↓33%)	p <0.001	−4.29 (↓32%)	p <0.001
Cortisol ug/dL (HSb, HSstim, LSb, LSstim)‡	−0.23	p =0.667	−1.64	p =0.763
Aldosterone ng/dl on HS (b,stim)§	−1.72 (↓18%)	p <0.001	−1.53 (↓18%)	p <0.001
Aldosterone ng/dl on LS b,stim) ||	−6.67 (↓35%)	p <0.001	−6.17 (↓34%)	p <0.001

^*Mixed Model 1: adjusted by age, BMI, gender and urinary sodium.

^†Mixed Model 2: covariates in model 1 plus race, site, and sodium diet order

^‡High sodium (HS) baseline (b), HS Angiotensin II stimulation (stim), Low sodium (LS) b, LS stim (1122 observations)

^§High sodium baseline (b), HS Angiotensin II stimulation (stim) (494 observations)

^||Low sodium baseline (b), LS Angiotensin II stimulation (stim) (628 observations)