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. 1993 Feb;48(2):103–109. doi: 10.1136/thx.48.2.103

Mediator and cytokine mechanisms in asthma.

S Holgate 1
PMCID: PMC464282  PMID: 8493621

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Selected References

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  1. Anderson S. D. Is there a unifying hypothesis for exercise-induced asthma? J Allergy Clin Immunol. 1984 May;73(5 Pt 2):660–665. doi: 10.1016/0091-6749(84)90301-4. [DOI] [PubMed] [Google Scholar]
  2. Arshad S. H., Hide D. W. Effect of environmental factors on the development of allergic disorders in infancy. J Allergy Clin Immunol. 1992 Aug;90(2):235–241. doi: 10.1016/0091-6749(92)90077-f. [DOI] [PubMed] [Google Scholar]
  3. Azzawi M., Bradley B., Jeffery P. K., Frew A. J., Wardlaw A. J., Knowles G., Assoufi B., Collins J. V., Durham S., Kay A. B. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1407–1413. doi: 10.1164/ajrccm/142.6_Pt_1.1407. [DOI] [PubMed] [Google Scholar]
  4. Beasley R., Roche W. R., Roberts J. A., Holgate S. T. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis. 1989 Mar;139(3):806–817. doi: 10.1164/ajrccm/139.3.806. [DOI] [PubMed] [Google Scholar]
  5. Berman J. S., Weller P. F. Airway eosinophils and lymphocytes in asthma. Birds of a feather? Am Rev Respir Dis. 1992 Jun;145(6):1246–1248. doi: 10.1164/ajrccm/145.6.1246. [DOI] [PubMed] [Google Scholar]
  6. Bousquet J., Chanez P., Lacoste J. Y., Barnéon G., Ghavanian N., Enander I., Venge P., Ahlstedt S., Simony-Lafontaine J., Godard P. Eosinophilic inflammation in asthma. N Engl J Med. 1990 Oct 11;323(15):1033–1039. doi: 10.1056/NEJM199010113231505. [DOI] [PubMed] [Google Scholar]
  7. Bradding P., Feather I. H., Howarth P. H., Mueller R., Roberts J. A., Britten K., Bews J. P., Hunt T. C., Okayama Y., Heusser C. H. Interleukin 4 is localized to and released by human mast cells. J Exp Med. 1992 Nov 1;176(5):1381–1386. doi: 10.1084/jem.176.5.1381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Broide D. H., Gleich G. J., Cuomo A. J., Coburn D. A., Federman E. C., Schwartz L. B., Wasserman S. I. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway. J Allergy Clin Immunol. 1991 Oct;88(4):637–648. doi: 10.1016/0091-6749(91)90158-k. [DOI] [PubMed] [Google Scholar]
  9. Burney P. G., Papacosta A. O., Withey C. H., Colley J. R., Holland W. W. Hospital admission rates and the prevalence of asthma symptoms in 20 local authority districts. Thorax. 1991 Aug;46(8):574–579. doi: 10.1136/thx.46.8.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Burr M. L., Butland B. K., King S., Vaughan-Williams E. Changes in asthma prevalence: two surveys 15 years apart. Arch Dis Child. 1989 Oct;64(10):1452–1456. doi: 10.1136/adc.64.10.1452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cookson W. O., Sharp P. A., Faux J. A., Hopkin J. M. Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet. 1989 Jun 10;1(8650):1292–1295. doi: 10.1016/s0140-6736(89)92687-1. [DOI] [PubMed] [Google Scholar]
  12. Cookson W. O., Young R. P., Sandford A. J., Moffatt M. F., Shirakawa T., Sharp P. A., Faux J. A., Julier C., Nakumuura Y., Nakumura Y. Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet. 1992 Aug 15;340(8816):381–384. doi: 10.1016/0140-6736(92)91468-n. [DOI] [PubMed] [Google Scholar]
  13. Denburg J. A., Dolovich J., Harnish D. Basophil mast cell and eosinophil growth and differentiation factors in human allergic disease. Clin Exp Allergy. 1989 May;19(3):249–254. doi: 10.1111/j.1365-2222.1989.tb02379.x. [DOI] [PubMed] [Google Scholar]
  14. Djukanović R., Lai C. K., Wilson J. W., Britten K. M., Wilson S. J., Roche W. R., Howarth P. H., Holgate S. T. Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls. Eur Respir J. 1992 May;5(5):538–544. [PubMed] [Google Scholar]
  15. Djukanović R., Wilson J. W., Britten K. M., Wilson S. J., Walls A. F., Roche W. R., Howarth P. H., Holgate S. T. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis. 1992 Mar;145(3):669–674. doi: 10.1164/ajrccm/145.3.669. [DOI] [PubMed] [Google Scholar]
  16. Djukanović R., Wilson J. W., Britten K. M., Wilson S. J., Walls A. F., Roche W. R., Howarth P. H., Holgate S. T. Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis. 1990 Oct;142(4):863–871. doi: 10.1164/ajrccm/142.4.863. [DOI] [PubMed] [Google Scholar]
  17. Dunnill M. S., Massarella G. R., Anderson J. A. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax. 1969 Mar;24(2):176–179. doi: 10.1136/thx.24.2.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Gleich G. J., Flavahan N. A., Fujisawa T., Vanhoutte P. M. The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity. J Allergy Clin Immunol. 1988 May;81(5 Pt 1):776–781. doi: 10.1016/0091-6749(88)90931-1. [DOI] [PubMed] [Google Scholar]
  19. Gleich G. J. The eosinophil and bronchial asthma: current understanding. J Allergy Clin Immunol. 1990 Feb;85(2):422–436. doi: 10.1016/0091-6749(90)90151-s. [DOI] [PubMed] [Google Scholar]
  20. Gordon J. R., Burd P. R., Galli S. J. Mast cells as a source of multifunctional cytokines. Immunol Today. 1990 Dec;11(12):458–464. doi: 10.1016/0167-5699(90)90176-a. [DOI] [PubMed] [Google Scholar]
  21. Gratziou C., Carroll M., Walls A., Howarth P. H., Holgate S. T. Early changes in T lymphocytes recovered by bronchoalveolar lavage after local allergen challenge of asthmatic airways. Am Rev Respir Dis. 1992 Jun;145(6):1259–1264. doi: 10.1164/ajrccm/145.6.1259. [DOI] [PubMed] [Google Scholar]
  22. Greve J. M., Davis G., Meyer A. M., Forte C. P., Yost S. C., Marlor C. W., Kamarck M. E., McClelland A. The major human rhinovirus receptor is ICAM-1. Cell. 1989 Mar 10;56(5):839–847. doi: 10.1016/0092-8674(89)90688-0. [DOI] [PubMed] [Google Scholar]
  23. Hamid Q., Azzawi M., Ying S., Moqbel R., Wardlaw A. J., Corrigan C. J., Bradley B., Durham S. R., Collins J. V., Jeffery P. K. Interleukin-5 mRNA in mucosal bronchial biopsies from asthmatic subjects. Int Arch Allergy Appl Immunol. 1991;94(1-4):169–170. doi: 10.1159/000235353. [DOI] [PubMed] [Google Scholar]
  24. Holgate S. T., Finnerty J. P. Recent advances in understanding the pathogenesis of asthma and its clinical implications. Q J Med. 1988 Jan;66(249):5–19. [PubMed] [Google Scholar]
  25. Holt P. G., Schon-Hegrad M. A., Oliver J., Holt B. J., McMenamin P. G. A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium. Int Arch Allergy Appl Immunol. 1990;91(2):155–159. doi: 10.1159/000235107. [DOI] [PubMed] [Google Scholar]
  26. Holt P. G., Schon-Hegrad M. A., Oliver J. MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J Exp Med. 1988 Feb 1;167(2):262–274. doi: 10.1084/jem.167.2.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Jeffery P. K., Wardlaw A. J., Nelson F. C., Collins J. V., Kay A. B. Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis. 1989 Dec;140(6):1745–1753. doi: 10.1164/ajrccm/140.6.1745. [DOI] [PubMed] [Google Scholar]
  28. Joce R., Wood D., Brown D., Begg N. Paralytic poliomyelitis in England and Wales, 1985-91. BMJ. 1992 Jul 11;305(6845):79–82. doi: 10.1136/bmj.305.6845.79. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Kleinerman J., Adelson L. A study of asthma deaths in a coroner's population. J Allergy Clin Immunol. 1987 Sep;80(3 Pt 2):406–409. doi: 10.1016/0091-6749(87)90061-3. [DOI] [PubMed] [Google Scholar]
  30. Laitinen L. A., Laitinen A., Haahtela T. A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. J Allergy Clin Immunol. 1992 Jul;90(1):32–42. doi: 10.1016/s0091-6749(06)80008-4. [DOI] [PubMed] [Google Scholar]
  31. Lemarchand P., Chinet T., Collignon M. A., Urzua G., Barritault L., Huchon G. J. Bronchial clearance of DTPA is increased in acute asthma but not in chronic asthma. Am Rev Respir Dis. 1992 Jan;145(1):147–152. doi: 10.1164/ajrccm/145.1.147. [DOI] [PubMed] [Google Scholar]
  32. Maggi E., Parronchi P., Manetti R., Simonelli C., Piccinni M. P., Rugiu F. S., De Carli M., Ricci M., Romagnani S. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol. 1992 Apr 1;148(7):2142–2147. [PubMed] [Google Scholar]
  33. Montefort S., Herbert C. A., Robinson C., Holgate S. T. The bronchial epithelium as a target for inflammatory attack in asthma. Clin Exp Allergy. 1992 May;22(5):511–520. doi: 10.1111/j.1365-2222.1992.tb00159.x. [DOI] [PubMed] [Google Scholar]
  34. Montefort S., Roberts J. A., Beasley R., Holgate S. T., Roche W. R. The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects. Thorax. 1992 Jul;47(7):499–503. doi: 10.1136/thx.47.7.499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Owen W. F., Jr, Soberman R. J., Yoshimoto T., Sheffer A. L., Lewis R. A., Austen K. F. Synthesis and release of leukotriene C4 by human eosinophils. J Immunol. 1987 Jan 15;138(2):532–538. [PubMed] [Google Scholar]
  36. Robinson D. S., Hamid Q., Ying S., Tsicopoulos A., Barkans J., Bentley A. M., Corrigan C., Durham S. R., Kay A. B. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med. 1992 Jan 30;326(5):298–304. doi: 10.1056/NEJM199201303260504. [DOI] [PubMed] [Google Scholar]
  37. Roche W. R., Beasley R., Williams J. H., Holgate S. T. Subepithelial fibrosis in the bronchi of asthmatics. Lancet. 1989 Mar 11;1(8637):520–524. doi: 10.1016/s0140-6736(89)90067-6. [DOI] [PubMed] [Google Scholar]
  38. Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today. 1991 Aug;12(8):256–257. doi: 10.1016/0167-5699(91)90120-I. [DOI] [PubMed] [Google Scholar]
  39. Schleimer R. P., Sterbinsky S. A., Kaiser J., Bickel C. A., Klunk D. A., Tomioka K., Newman W., Luscinskas F. W., Gimbrone M. A., Jr, McIntyre B. W. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol. 1992 Feb 15;148(4):1086–1092. [PubMed] [Google Scholar]
  40. Sporik R., Holgate S. T., Platts-Mills T. A., Cogswell J. J. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990 Aug 23;323(8):502–507. doi: 10.1056/NEJM199008233230802. [DOI] [PubMed] [Google Scholar]
  41. Springer T. A. Adhesion receptors of the immune system. Nature. 1990 Aug 2;346(6283):425–434. doi: 10.1038/346425a0. [DOI] [PubMed] [Google Scholar]
  42. Stewart G. A., Thompson P. J., Simpson R. J. Protease antigens from house dust mite. Lancet. 1989 Jul 15;2(8655):154–155. doi: 10.1016/s0140-6736(89)90203-1. [DOI] [PubMed] [Google Scholar]
  43. Taylor I. K., O'Shaughnessy K. M., Fuller R. W., Dollery C. T. Effect of cysteinyl-leukotriene receptor antagonist ICI 204.219 on allergen-induced bronchoconstriction and airway hyperreactivity in atopic subjects. Lancet. 1991 Mar 23;337(8743):690–694. doi: 10.1016/0140-6736(91)90277-v. [DOI] [PubMed] [Google Scholar]
  44. Tomioka M., Ida S., Shindoh Y., Ishihara T., Takishima T. Mast cells in bronchoalveolar lumen of patients with bronchial asthma. Am Rev Respir Dis. 1984 Jun;129(6):1000–1005. doi: 10.1164/arrd.1984.129.6.1000. [DOI] [PubMed] [Google Scholar]
  45. Walsh G. M., Mermod J. J., Hartnell A., Kay A. B., Wardlaw A. J. Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent. J Immunol. 1991 May 15;146(10):3419–3423. [PubMed] [Google Scholar]
  46. Wilson J. W., Djukanović R., Howarth P. H., Holgate S. T. Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma. Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):958–960. doi: 10.1164/ajrccm/145.4_Pt_1.958. [DOI] [PubMed] [Google Scholar]
  47. Yoshida M., Romberger D. J., Illig M. G., Takizawa H., Sacco O., Spurzem J. R., Sisson J. H., Rennard S. I., Beckmann J. D. Transforming growth factor-beta stimulates the expression of desmosomal proteins in bronchial epithelial cells. Am J Respir Cell Mol Biol. 1992 Apr;6(4):439–445. doi: 10.1165/ajrcmb/6.4.439. [DOI] [PubMed] [Google Scholar]
  48. Young R. P., Sharp P. A., Lynch J. R., Faux J. A., Lathrop G. M., Cookson W. O., Hopkin J. M. Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13. J Med Genet. 1992 Apr;29(4):236–238. doi: 10.1136/jmg.29.4.236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. de Blay F., Chapman M. D., Platts-Mills T. A. Airborne cat allergen (Fel d I). Environmental control with the cat in situ. Am Rev Respir Dis. 1991 Jun;143(6):1334–1339. doi: 10.1164/ajrccm/143.6.1334. [DOI] [PubMed] [Google Scholar]

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