There are formatting errors in Table 1. Please see the corrected Table 1 below.
Table 1. Classification and biological roles of HDACs.
Classes | Cofactors | HDACs | Cellular Locations | Biological Processes | References |
---|---|---|---|---|---|
Class I | Zn+2 dependent | 1, 2, 3, 8 | Nucleus, Cytoplasm, Transcriptional repressor complex, Spindle microtubule, Replication fork | Cell cycle regulation, Cell differentiation, DNA damage response, Epidermis development, Regulating cardiac myocyte proliferation on the course of cardiac development | [16–18] |
Class II | Zn+2 dependent | 4, 5, 6, 7, 9, 10 | Cytoplasm, Nucleus, Neuromuscular junction, Golgi apparatus, Cytosol caveola | Regulation of transcription and cell differentiation, Regulation of cardiac muscle contraction, Inflammatory response, Nervous system development, Heart development, Protein polyubiquitination, Response to toxic and organic substances, Macroautophagy, Vasculogenesis | [1, 17] |
Class III | NAD+ dependent | Sirtuins SIRT1-SIRT7 | Nucleus, Cytoplasm | Histone deacetylation, Regulation of phosphorylation, Regulation of double-strand break repair via homologous recombination, DNA repair mechanism | [16] |
Class IV | Zn+2 dependent | 11 | Nucleus | Transcription, DNA-dependent chromatin modification, Histone Deacetylation | [16] |
Reference
- 1. Noor Z, Afzal N, Rashid S (2015) Exploration of Novel Inhibitors for Class I Histone Deacetylase Isoforms by QSAR Modeling and Molecular Dynamics Simulation Assays. PLoS ONE 10(10): e0139588 doi:10.1371/journal.pone.0139588 [DOI] [PMC free article] [PubMed] [Google Scholar]