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. 2015 Nov 12;10(11):e0143155. doi: 10.1371/journal.pone.0143155

Correction: Exploration of Novel Inhibitors for Class I Histone Deacetylase Isoforms by QSAR Modeling and Molecular Dynamics Simulation Assays

Zainab Noor, Noreen Afzal, Sajid Rashid
PMCID: PMC4642989  PMID: 26562411

There are formatting errors in Table 1. Please see the corrected Table 1 below.

Table 1. Classification and biological roles of HDACs.

Classes Cofactors HDACs Cellular Locations Biological Processes References
Class I Zn+2 dependent 1, 2, 3, 8 Nucleus, Cytoplasm, Transcriptional repressor complex, Spindle microtubule, Replication fork Cell cycle regulation, Cell differentiation, DNA damage response, Epidermis development, Regulating cardiac myocyte proliferation on the course of cardiac development [16–18]
Class II Zn+2 dependent 4, 5, 6, 7, 9, 10 Cytoplasm, Nucleus, Neuromuscular junction, Golgi apparatus, Cytosol caveola Regulation of transcription and cell differentiation, Regulation of cardiac muscle contraction, Inflammatory response, Nervous system development, Heart development, Protein polyubiquitination, Response to toxic and organic substances, Macroautophagy, Vasculogenesis [1, 17]
Class III NAD+ dependent Sirtuins SIRT1-SIRT7 Nucleus, Cytoplasm Histone deacetylation, Regulation of phosphorylation, Regulation of double-strand break repair via homologous recombination, DNA repair mechanism [16]
Class IV Zn+2 dependent 11 Nucleus Transcription, DNA-dependent chromatin modification, Histone Deacetylation [16]

Reference


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