Erratum to: Eur J Epidemiol (2014) 29:605–612 DOI 10.1007/s10654-014-9932-1
Computing errors in our paper introduced small errors. We here provide the corrected estimates together with correct versions of the six tables (Tables 1, 2, 3, 5, 6, 7) that contained errors (available on the journal website linked to this paper). The authors apologize for the inconvenience caused by the following errors.
Table 1.
Taking polypill from specified age to age 99 | Proportion of people who will have first MI or stroke in the absence of treatment (%) | Proportion of people who will have first MI or stroke while taking polypill (%) | Relative risk reduction (%) | Absolute annual risk reduction (%) | Proportion of people who benefit (HBp) (%) | Among those who benefit: Average years of life gained without an MI or stroke (HBag) |
---|---|---|---|---|---|---|
50 | 34 | 16 | 53 | 0.53 | 34 | 7.7 |
60 | 33 | 16 | 52 | 0.69 | 33 | 6.5 |
70 | 32 | 16 | 51 | 0.95 | 32 | 5.1 |
80 | 29 | 15 | 49 | 1.41 | 29 | 3.4 |
Table 2.
Salt reduction (g/day) | Proportion of people who will have first MI or stroke in the absence of treatment (%) | Proportion of people who will have first MI or stroke with a reduced salt intake (%) | Relative risk reduction (%) | Absolute annual risk reduction (%) | Proportion of people who benefit (HBp) (%) | Among those who benefit: average years of life gained without an MI or stroke (HBag) |
---|---|---|---|---|---|---|
1.5 | 34 | 32 | 4 | 0.04 | 34 | 0.7 |
3.0 | 34 | 31 | 8 | 0.09 | 34 | 1.4 |
4.5 | 34 | 30 | 12 | 0.13 | 34 | 2.0 |
6.0 | 34 | 28 | 16 | 0.17 | 34 | 2.6 |
Table 3.
Reducing salt by 6 g/day | Taking simvastatin 20 mg daily from age 50 | Taking three blood-pressure-lowering drugs at half standard dose daily from age 50 | Taking polypill daily from age 50 (all four drugs) | Reducing salt by 6 g/day and taking polypill daily from age 50 | |
---|---|---|---|---|---|
Proportion who benefit (HBp) | 34 % | 34 % | 34 % | 34 % | 34 % |
Among these: average years of life gained without an MI or stroke (HBag) | 2.6 | 3.7 | 5.5 | 7.7 | 8.7 |
Table 5.
Age taking polypill | Relative risk of a first stroke on daily polypilla | Relative risk of a first myocardial infarction on daily polypilla |
---|---|---|
50 | 0.26 | 0.13 |
60 | 0.28 | 0.23 |
70 | 0.34 | 0.32 |
80 | 0.44 | 0.36 |
90+ | 0.51 | 0.38 |
aPolypill contained amlodipine 2.5 mg, losartan 25 mg, hydrochlorothiazide 12.5 mg and simvastatin 20 mg
Table 6.
Years of follow-up | Age starting to take polypill daily | |||
---|---|---|---|---|
50 | 60 | 70 | 80 | |
10 | 78 | 71 | 63 | 54 |
20 | 73 | 64 | 55 | 49 |
30 | 66 | 57 | 51 | – |
40 | 58 | 52 | – | – |
50 | 53 | – | – | – |
Table 7.
Age | 1.5 g/day | 3.0 g/day | 4.5 g/day | 6 g/day | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
SBP reduction (mmHg) | Relative risk of a first MI | Relative risk of a first stroke | SBP reduction (mmHg) | Relative risk of a first MI | Relative risk of a first stroke | SBP reduction (mmHg) | Relative risk of a first MI | Relative risk of a first stroke | SBP reduction (mmHg) | Relative risk of a first MI | Relative risk of a first stroke | |
45 | 1.7 | 0.93 | 0.91 | 3.3 | 0.87 | 0.83 | 4.9 | 0.82 | 0.75 | 6.6 | 0.76 | 0.69 |
55 | 2.3 | 0.92 | 0.88 | 4.6 | 0.85 | 0.77 | 6.9 | 0.79 | 0.67 | 9.2 | 0.73 | 0.60 |
65 | 2.6 | 0.94 | 0.90 | 5.2 | 0.88 | 0.82 | 7.7 | 0.82 | 0.74 | 10.3 | 0.77 | 0.67 |
75 | 2.7 | 0.95 | 0.92 | 5.4 | 0.90 | 0.85 | 8.1 | 0.85 | 0.78 | 10.8 | 0.81 | 0.72 |
85 | 2.7 | 0.96 | 0.95 | 5.5 | 0.92 | 0.90 | 8.2 | 0.89 | 0.86 | 11.0 | 0.85 | 0.82 |
Abstract
Under the holistic model, 34 % (not 33 %) of people who take the polypill from age 50 benefit, gaining on average 7.7 (not 8.0) years of life without an MI or stroke (18 % benefit under the reductionist model—not 19 %). Estimates for reducing salt intake by 6 g/day are 34 % and 2.6 years, respectively, (not 33 % and 2.8 years) under the holistic model and 5 % (not 6 %) under the reductionist model.
Results
Para 1: 56 % should read 53 %. 0.37 % should read 0.53 %. 33 % should read 34 %. 8.0 years should read 7.7 years. 67 % should read 66 %.
Para 2: 33 % should read 34 %, 8.0 years should read 7.7 years.
Para 3: 33 % should read 34 %.
Para 4: 33 % should read 34 %, 2.8 years should read 2.6 years and 8.8 years should read 8.7 years.
Discussion
Para 2: 19 % should read 18 %, 33 % should read 34 %, 15 % should read 16 %, 8.0 should read 7.7.
Para 3: 33 % should read 34 %, 2.8 years should read 2.6 years, 6 % should read 5 %.
Para 4: 81 % should read 78 %, 55 % should read 54 %, 1.0 % should read 1.33 %.
Para 5: 33 % should read 34 %, 50 % should read 46 %.
Appendix
Section 2: Estimating the age specific relative risk of a myocardial infarction or stroke on the Polypill.
Para 2: 56 % should read 53 %, 81 % should read 78 %.
Footnotes
The online version of the original article can be found under doi:10.1007/s10654-014-9932-1.