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. Author manuscript; available in PMC: 2015 Nov 13.
Published in final edited form as: Gastroenterology. 2009 Sep 2;138(1):197–209. doi: 10.1053/j.gastro.2009.08.054

Figure 7.

Figure 7

HIV PIs activate the UPR and induce damage in intestine. Mice were treated with individual HIV PIs (50 mg/kg) for 2–4 weeks. (A) Representative immunoblots of nuclear extracts isolated from intestine tissues against CHOP, XBP-1, and lamin B are shown. (B) Representative images of H&E staining for each treatment group is shown. (C and D) Histologic score of HIV PI-induced epithelial tissue damage and neutrophil infiltration. Statistical significance relative to vehicle control: *P < .05, **P < .01, ***P < .001.