Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1993 Apr;48(4):396–400. doi: 10.1136/thx.48.4.396

A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a hypothesis.

J A Karlsson 1
PMCID: PMC464441  PMID: 8511740

Full text

PDF
396

Images in this article

398Image
on p.398

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alving K., Matran R., Lacroix J. S., Lundberg J. M. Allergen challenge induces vasodilatation in pig bronchial circulation via a capsaicin-sensitive mechanism. Acta Physiol Scand. 1988 Dec;134(4):571–572. doi: 10.1111/j.1748-1716.1998.tb08537.x. [DOI] [PubMed] [Google Scholar]
  2. Barnes P. J. Asthma as an axon reflex. Lancet. 1986 Feb 1;1(8475):242–245. doi: 10.1016/s0140-6736(86)90777-4. [DOI] [PubMed] [Google Scholar]
  3. Barnes P. J., Baraniuk J. N., Belvisi M. G. Neuropeptides in the respiratory tract. Part I. Am Rev Respir Dis. 1991 Nov;144(5):1187–1198. doi: 10.1164/ajrccm/144.5.1187. [DOI] [PubMed] [Google Scholar]
  4. Barnes P. J., Brown M. J., Dollery C. T., Fuller R. W., Heavey D. J., Ind P. W. Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex. Br J Pharmacol. 1986 Aug;88(4):741–745. doi: 10.1111/j.1476-5381.1986.tb16246.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bascom R., Kagey-Sobotka A., Proud D. Effect of intranasal capsaicin on symptoms and mediator release. J Pharmacol Exp Ther. 1991 Dec;259(3):1323–1327. [PubMed] [Google Scholar]
  6. Castairs J. R., Barnes P. J. Autoradiographic mapping of substance P receptors in lung. Eur J Pharmacol. 1986 Aug 15;127(3):295–296. doi: 10.1016/0014-2999(86)90380-8. [DOI] [PubMed] [Google Scholar]
  7. Cheung D., Bel E. H., Den Hartigh J., Dijkman J. H., Sterk P. J. The effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responses to neurokinin A in normal humans in vivo. Am Rev Respir Dis. 1992 Jun;145(6):1275–1280. doi: 10.1164/ajrccm/145.6.1275. [DOI] [PubMed] [Google Scholar]
  8. Choudry N. B., Fuller R. W. Sensitivity of the cough reflex in patients with chronic cough. Eur Respir J. 1992 Mar;5(3):296–300. [PubMed] [Google Scholar]
  9. Coleridge H. M., Coleridge J. C., Luck J. C. Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs. J Physiol. 1965 Jul;179(2):248–262. doi: 10.1113/jphysiol.1965.sp007660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Colpaert F. C., Donnerer J., Lembeck F. Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis. Life Sci. 1983 Apr 18;32(16):1827–1834. doi: 10.1016/0024-3205(83)90060-7. [DOI] [PubMed] [Google Scholar]
  11. Davis B., Roberts A. M., Coleridge H. M., Coleridge J. C. Reflex tracheal gland secretion evoked by stimulation of bronchial C-fibers in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1982 Oct;53(4):985–991. doi: 10.1152/jappl.1982.53.4.985. [DOI] [PubMed] [Google Scholar]
  12. Devillier P., Dessanges J. F., Rakotosihanaka F., Ghaem A., Boushey H. A., Lockhart A., Marsac J. Nasal response to substance P and methacholine in subjects with and without allergic rhinitis. Eur Respir J. 1988 Apr;1(4):356–361. [PubMed] [Google Scholar]
  13. Dunér-Engström M., Fredholm B. B., Larsson O., Lundberg J. M., Saria A. Autonomic mechanisms underlying capsaicin induced oral sensations and salivation in man. J Physiol. 1986 Apr;373:87–96. doi: 10.1113/jphysiol.1986.sp016036. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Finney M. J., Karlsson J. A., Persson C. G. Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. Br J Pharmacol. 1985 May;85(1):29–36. doi: 10.1111/j.1476-5381.1985.tb08827.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Forsberg K., Karlsson J. A., Theodorsson E., Lundberg J. M., Persson C. G. Cough and bronchoconstriction mediated by capsaicin-sensitive sensory neurons in the guinea-pig. Pulm Pharmacol. 1988;1(1):33–39. doi: 10.1016/0952-0600(88)90008-7. [DOI] [PubMed] [Google Scholar]
  16. Fuller R. W., Choudry N. B. Increased cough reflex associated with angiotensin converting enzyme inhibitor cough. Br Med J (Clin Res Ed) 1987 Oct 24;295(6605):1025–1026. doi: 10.1136/bmj.295.6605.1025-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Fuller R. W., Dixon C. M., Barnes P. J. Bronchoconstrictor response to inhaled capsaicin in humans. J Appl Physiol (1985) 1985 Apr;58(4):1080–1084. doi: 10.1152/jappl.1985.58.4.1080. [DOI] [PubMed] [Google Scholar]
  18. Fuller R. W., Maxwell D. L., Dixon C. M., McGregor G. P., Barnes V. F., Bloom S. R., Barnes P. J. Effect of substance P on cardiovascular and respiratory function in subjects. J Appl Physiol (1985) 1987 Apr;62(4):1473–1479. doi: 10.1152/jappl.1987.62.4.1473. [DOI] [PubMed] [Google Scholar]
  19. Garret C., Carruette A., Fardin V., Moussaoui S., Peyronel J. F., Blanchard J. C., Laduron P. M. Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10208–10212. doi: 10.1073/pnas.88.22.10208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Geppetti P., Fusco B. M., Marabini S., Maggi C. A., Fanciullacci M., Sicuteri F. Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man. Br J Pharmacol. 1988 Mar;93(3):509–514. doi: 10.1111/j.1476-5381.1988.tb10305.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Hansson L., Wollmer P., Dahlbäck M., Karlsson J. A. Regional sensitivity of human airways to capsaicin-induced cough. Am Rev Respir Dis. 1992 May;145(5):1191–1195. doi: 10.1164/ajrccm/145.5.1191. [DOI] [PubMed] [Google Scholar]
  22. Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience. 1988 Mar;24(3):739–768. doi: 10.1016/0306-4522(88)90064-4. [DOI] [PubMed] [Google Scholar]
  23. Howard P., Cayton R. M., Brennan S. R., Anderson P. B. Lignocaine aerosol and persistent cough. Br J Dis Chest. 1977 Jan;71(1):19–24. [PubMed] [Google Scholar]
  24. Ichinose M., Inoue H., Miura M., Yafuso N., Nogami H., Takishima T. Possible sensory receptor of nonadrenergic inhibitory nervous system. J Appl Physiol (1985) 1987 Sep;63(3):923–929. doi: 10.1152/jappl.1987.63.3.923. [DOI] [PubMed] [Google Scholar]
  25. Joos G. F., Pauwels R. A., Van der Straeten M. E. The effect of nedocromil sodium on the bronchoconstrictor effect of neurokinin A in subjects with asthma. J Allergy Clin Immunol. 1989 Mar;83(3):663–668. doi: 10.1016/0091-6749(89)90080-8. [DOI] [PubMed] [Google Scholar]
  26. Joos G., Pauwels R., Van Der Straeten M. The effect of oxitropium bromide on neurokinin A-induced bronchoconstriction in asthmatic subjects. Pulm Pharmacol. 1988;1(1):41–45. doi: 10.1016/0952-0600(88)90009-9. [DOI] [PubMed] [Google Scholar]
  27. Joos G., Pauwels R., van der Straeten M. Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax. 1987 Oct;42(10):779–783. doi: 10.1136/thx.42.10.779. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Karlsson J. A., Persson C. G. Evidence against vasoactive intestinal polypeptide (VIP) as a dilator and in favour of substance P as a constrictor in airway neurogenic responses. Br J Pharmacol. 1983 Jul;79(3):634–636. doi: 10.1111/j.1476-5381.1983.tb09999.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Karlsson J. A., Persson C. G. Novel peripheral neurotransmitters and control of the airways. Pharmacol Ther. 1989;43(3):397–423. doi: 10.1016/0163-7258(89)90018-1. [DOI] [PubMed] [Google Scholar]
  30. Karlsson J. A., Sant'Ambrogio G., Widdicombe J. Afferent neural pathways in cough and reflex bronchoconstriction. J Appl Physiol (1985) 1988 Sep;65(3):1007–1023. doi: 10.1152/jappl.1988.65.3.1007. [DOI] [PubMed] [Google Scholar]
  31. Karlsson J. A., Zackrisson C., Lundberg J. M. Hyperresponsiveness to tussive stimuli in cigarette smoke-exposed guinea-pigs: a role for capsaicin-sensitive, calcitonin gene-related peptide-containing nerves. Acta Physiol Scand. 1991 Apr;141(4):445–454. doi: 10.1111/j.1748-1716.1991.tb09105.x. [DOI] [PubMed] [Google Scholar]
  32. Kröll F., Karlsson J. A., Lundberg J. M., Persson C. G. Capsaicin-induced bronchoconstriction and neuropeptide release in guinea pig perfused lungs. J Appl Physiol (1985) 1990 Apr;68(4):1679–1687. doi: 10.1152/jappl.1990.68.4.1679. [DOI] [PubMed] [Google Scholar]
  33. Lacroix J. S., Buvelot J. M., Polla B. S., Lundberg J. M. Improvement of symptoms of non-allergic chronic rhinitis by local treatment with capsaicin. Clin Exp Allergy. 1991 Sep;21(5):595–600. doi: 10.1111/j.1365-2222.1991.tb00852.x. [DOI] [PubMed] [Google Scholar]
  34. Levine J. D., Dardick S. J., Roizen M. F., Helms C., Basbaum A. I. Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. J Neurosci. 1986 Dec;6(12):3423–3429. doi: 10.1523/JNEUROSCI.06-12-03423.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Lundberg J. M., Hökfelt T., Martling C. R., Saria A., Cuello C. Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res. 1984;235(2):251–261. doi: 10.1007/BF00217848. [DOI] [PubMed] [Google Scholar]
  36. Lundberg J. M., Saria A. Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature. 1983 Mar 17;302(5905):251–253. doi: 10.1038/302251a0. [DOI] [PubMed] [Google Scholar]
  37. Lundblad L., Lundberg J. M., Anggård A., Zetterström O. Capsaicin-sensitive nerves and the cutaneous allergy reaction in man. Possible involvement of sensory neuropeptides in the flare reaction. Allergy. 1987 Jan;42(1):20–25. doi: 10.1111/j.1398-9995.1987.tb02182.x. [DOI] [PubMed] [Google Scholar]
  38. Martling C. R., Gazelius B., Lundberg J. M. Nervous control of tracheal blood flow in the cat measured by the laser Doppler technique. Acta Physiol Scand. 1987 Jul;130(3):409–417. doi: 10.1111/j.1748-1716.1987.tb08156.x. [DOI] [PubMed] [Google Scholar]
  39. Martling C. R., Theodorsson-Norheim E., Lundberg J. M. Occurrence and effects of multiple tachykinins; substance P, neurokinin A and neuropeptide K in human lower airways. Life Sci. 1987 Apr 20;40(16):1633–1643. doi: 10.1016/0024-3205(87)90130-5. [DOI] [PubMed] [Google Scholar]
  40. Minami M., Kuraishi Y., Kawamura M., Yamaguchi T., Masu Y., Nakanishi S., Satoh M. Enhancement of preprotachykinin A gene expression by adjuvant-induced inflammation in the rat spinal cord: possible involvement of substance P-containing spinal neurons in nociception. Neurosci Lett. 1989 Mar 13;98(1):105–110. doi: 10.1016/0304-3940(89)90382-0. [DOI] [PubMed] [Google Scholar]
  41. Nichol G. M., O'Connor B. J., Lecomte J. M., Chung K. F., Barnes P. J. Effect of neutral endopeptidase inhibitor on airway function and bronchial responsiveness in asthmatic subjects. Eur J Clin Pharmacol. 1992;42(5):491–494. doi: 10.1007/BF00314856. [DOI] [PubMed] [Google Scholar]
  42. Ollerenshaw S. L., Jarvis D., Sullivan C. E., Woolcock A. J. Substance P immunoreactive nerves in airways from asthmatics and nonasthmatics. Eur Respir J. 1991 Jun;4(6):673–682. [PubMed] [Google Scholar]
  43. Salonen R. O., Webber S. E., Widdicombe J. G. Effects of neuropeptides and capsaicin on the canine tracheal vasculature in vivo. Br J Pharmacol. 1988 Dec;95(4):1262–1270. doi: 10.1111/j.1476-5381.1988.tb11763.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Sanders R. V., Kirkpatrick M. B. Prolonged suppression of cough after inhalation of lidocaine in a patient with sarcoid. JAMA. 1984 Nov 2;252(17):2456–2457. [PubMed] [Google Scholar]
  45. Snider R. M., Constantine J. W., Lowe J. A., 3rd, Longo K. P., Lebel W. S., Woody H. A., Drozda S. E., Desai M. C., Vinick F. J., Spencer R. W. A potent nonpeptide antagonist of the substance P (NK1) receptor. Science. 1991 Jan 25;251(4992):435–437. doi: 10.1126/science.1703323. [DOI] [PubMed] [Google Scholar]
  46. Stjärne P., Lundblad L., Lundberg J. M., Anggård A. Capsaicin and nicotine-sensitive afferent neurones and nasal secretion in healthy human volunteers and in patients with vasomotor rhinitis. Br J Pharmacol. 1989 Mar;96(3):693–701. doi: 10.1111/j.1476-5381.1989.tb11870.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES