Cumulative 7 day food intake (A) and bodyweight change (B) after daily administration of OXM15 at various doses. Average starting weight 542 g. Vehicle, OXM(50), OXM(10) n = 9/group; all other groups n = 10/group. Data represent mean ± SEM. Significance calculated using one way ANOVA (A, F = 3.503, P = 0.0089; B, F = 27.13, P < 0.0001) with Dunnett’s post hoc test (***P < 0.001 vs vehicle controls).