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. 1993 May 1;90(9):4122–4126. doi: 10.1073/pnas.90.9.4122

Loss of function of the Drosophila zfh-1 gene results in abnormal development of mesodermally derived tissues.

Z C Lai 1, E Rushton 1, M Bate 1, G M Rubin 1
PMCID: PMC46458  PMID: 8097886

Abstract

The Drosophila zfh-1 gene encodes an unusual protein with nine Cys2His2 type zinc-finger motifs and one homeodomain that shows a complex pattern of expression in the embryonic mesoderm and nervous system. To study the function of zfh-1, we generated loss-of-function zfh-1 mutations. Phenotypic analysis of zfh-1 mutant embryos reveals that the gene is not required for the initial segregation of the mesoderm or for the differentiation of mesodermally derived tissues. Rather, loss of zfh-1 function results in various degrees of local errors in cell fate or positioning.

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Selected References

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