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. 1993 Jun;48(6):619–621. doi: 10.1136/thx.48.6.619

Serum titres of Pneumocystis carinii antibody in health care workers caring for patients with AIDS.

T R Leigh 1, M J Millett 1, B Jameson 1, J V Collins 1
PMCID: PMC464586  PMID: 8346492

Abstract

BACKGROUND--Pneumocystis carinii pneumonia was thought to occur from reactivation of latent infection, but recent studies with the polymerase chain reaction have failed to detect P carinii in normal subjects. If pneumocystis pneumonia is therefore caused by new infection the source and mode of transmission of P carinii remains unknown. METHODS--Natural exposure to P carinii was detected by measuring antibodies by indirect immunofluorescence in 24 health care workers working continuously with patients with AIDS and 24 control health care workers exclusively treating elderly patients. RESULTS--P carinii antibody titres were significantly higher in the health care workers exposed to AIDS than in the control group (median titre 1:32 v 1:16 respectively). Three control subjects had no antibodies compared with none of the subjects exposed to AIDS, and 10 of the 12 highest titres came from the exposed group. CONCLUSIONS--Raised P carinii antibody titres in health care workers caring for patients with AIDS suggest that patients infected with HIV may be a potentially infectious source of P carinii for susceptible subjects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett C. L., Gertler P., Guze P. A., Garfinkle J. B., Kanouse D. E., Greenfield S. The relation between resource use and in-hospital mortality for patients with acquired immunodeficiency syndrome-related Pneumocystis carinii pneumonia. Arch Intern Med. 1990 Jul;150(7):1447–1452. [PubMed] [Google Scholar]
  2. Chatterton J. M., Joss A. W., Williams H., Ho-Yen D. O. Pneumocystis carinii antibody testing. J Clin Pathol. 1989 Aug;42(8):865–868. doi: 10.1136/jcp.42.8.865. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hughes W. T. Natural mode of acquisition for de novo infection with Pneumocystis carinii. J Infect Dis. 1982 Jun;145(6):842–848. doi: 10.1093/infdis/145.6.842. [DOI] [PubMed] [Google Scholar]
  4. Kovacs J. A., Halpern J. L., Swan J. C., Moss J., Parrillo J. E., Masur H. Identification of antigens and antibodies specific for Pneumocystis carinii. J Immunol. 1988 Mar 15;140(6):2023–2031. [PubMed] [Google Scholar]
  5. Leigh T. R., Wakefield A. E., Peters S. E., Hopkin J. M., Collins J. V. Comparison of DNA amplification and immunofluorescence for detecting Pneumocystis carinii in patients receiving immunosuppressive therapy. Transplantation. 1992 Sep;54(3):468–470. doi: 10.1097/00007890-199209000-00016. [DOI] [PubMed] [Google Scholar]
  6. Masur H., Lane H. C., Kovacs J. A., Allegra C. J., Edman J. C. NIH conference. Pneumocystis pneumonia: from bench to clinic. Ann Intern Med. 1989 Nov 15;111(10):813–826. doi: 10.7326/0003-4819-111-10-813. [DOI] [PubMed] [Google Scholar]
  7. Meuwissen J. H., Tauber I., Leeuwenberg A. D., Beckers P. J., Sieben M. Parasitologic and serologic observations of infection with Pneumocystis in humans. J Infect Dis. 1977 Jul;136(1):43–49. doi: 10.1093/infdis/136.1.43. [DOI] [PubMed] [Google Scholar]
  8. Murray J. F., Mills J. Pulmonary infectious complications of human immunodeficiency virus infection. Part II. Am Rev Respir Dis. 1990 Jun;141(6):1582–1598. doi: 10.1164/ajrccm/141.6.1582. [DOI] [PubMed] [Google Scholar]
  9. Peglow S. L., Smulian A. G., Linke M. J., Pogue C. L., Nurre S., Crisler J., Phair J., Gold J. W., Armstrong D., Walzer P. D. Serologic responses to Pneumocystis carinii antigens in health and disease. J Infect Dis. 1990 Feb;161(2):296–306. doi: 10.1093/infdis/161.2.296. [DOI] [PubMed] [Google Scholar]
  10. Peters S. E., Wakefield A. E., Sinclair K., Millard P. R., Hopkin J. M. A search for Pneumocystis carinii in post-mortem lungs by DNA amplification. J Pathol. 1992 Feb;166(2):195–198. doi: 10.1002/path.1711660217. [DOI] [PubMed] [Google Scholar]
  11. Pifer L. L., Hughes W. T., Stagno S., Woods D. Pneumocystis carinii infection: evidence for high prevalence in normal and immunosuppressed children. Pediatrics. 1978 Jan;61(1):35–41. [PubMed] [Google Scholar]
  12. Shepherd V., Jameson B., Knowles G. K. Pneumocystis carinii pneumonitis: a serological study. J Clin Pathol. 1979 Aug;32(8):773–777. doi: 10.1136/jcp.32.8.773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Singer C., Armstrong D., Rosen P. P., Schottenfeld D. Pneumocystis carinii pneumonia: a cluster of eleven cases. Ann Intern Med. 1975 Jun;82(6):772–777. doi: 10.7326/0003-4819-82-6-722. [DOI] [PubMed] [Google Scholar]

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