Table 2.
Biochemical parameters
| All adenomas n = 53 | μAs n = 37 | MAs n = 16 | P value μA vs. MA | |
|---|---|---|---|---|
| Random ACTH (pg/ml) | 71.9 ± 4.6 (n = 50) | 69.5 ± 5.3 (n = 36) | 78.3 ± 8.9 (n = 14) | 0.390 |
| Random cortisol (mcg/dl) | 23.5 ± 1.5 (n = 45) | 25.9 ± 1.8 (n = 31) | 18.2 ± 2.4 (n = 14) | 0.018 |
| Cortisol:ACTH ratioa | 0.37 ± 0.03 (n = 48) | 0.42 ± 0.05 (n = 34) | 0.25 ± 0.03 (n = 14) | 0.048 |
| Mean fold elevation in 24 h UFC | 4.4 ± 0.9 (n = 44) | 4.9 ± 1.1 (n = 33) | 2.9 ± 0.9 (n = 11) | 0.34 |
| Mean fold elevation in salivary cortisol | 4.6 ± 0.8 (n = 26) | 4.9 ± 1.1 (n = 20) | 3.1 ± 0.7 (n = 6) | 0.36 |
| Mean serum cortisol after 1 mg DST (mcg/dl) | 15.7 ± 1.6 (n = 30) | 16.7 ± 1.9 (n = 20) | 14.1 ± 2.7 (n = 10) | 0.49 |
| Mean serum cortisol after 8 mg DST (mcg/dl) | 6.29 ± 1.37 (n = 25) | 7.41 ± 1.62 (n = 20) | 1.83 ± 0.58 (n = 5) | 0.10 |
| % suppressibility in serum cortisol after 8 mg DST | 74.3 ± 5.4 (n = 25) | 71.5 ± 5.9 (n = 20) | 90.2 ± 2.3 (n = 5) | 0.14 |
Statistically significant P values are in bold
Values are means ± SEM
a
Derived from simultaneous measurements of random serum ACTH and cortisol