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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1993 May 1;90(9):4286–4289. doi: 10.1073/pnas.90.9.4286

Associative learning potentiates protein kinase C activation in synaptosomes of the rabbit hippocampus.

K Sunayashiki-Kusuzaki 1, D S Lester 1, B G Schreurs 1, D L Alkon 1
PMCID: PMC46491  PMID: 8483944

Abstract

Using electrophysiological, biochemical, and autoradiographic techniques, changes in protein kinase C (PKC) activity in specific regions of the hippocampus have been previously implicated in classical conditioning of the nictitating membrane response of the rabbit. Here we report that activation of PKC is potentiated 2- to 3-fold in synaptosomes of the hippocampal CA1 and CA2 to -3 regions in rabbits that have undergone classical conditioning of the nictitating membrane response. This potentiation is apparently due to a change in the biochemical properties of PKC within the synaptosomes and is not a result of an increase in total PKC activity. This observation correlates a subcellular biochemical change with classical conditioning of a mammal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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