Abstract
The efficacy of dry powder inhalers is dependent on the inspiratory flow rate at which they are used. The resistance to airflow through five different dry powder inhaler devices was measured. The devices were shown to vary significantly, with the Turbohaler having the highest resistance. We suggest that the performance of dry powder inhalers should be assessed at comparable pressure drops producing clinically relevant inspiratory flow rates for each device.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Engel T., Heinig J. H., Madsen F., Nikander K. Peak inspiratory flow and inspiratory vital capacity of patients with asthma measured with and without a new dry-powder inhaler device (Turbuhaler). Eur Respir J. 1990 Oct;3(9):1037–1041. [PubMed] [Google Scholar]
- Pedersen S., Hansen O. R., Fuglsang G. Influence of inspiratory flow rate upon the effect of a Turbuhaler. Arch Dis Child. 1990 Mar;65(3):308–310. doi: 10.1136/adc.65.3.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pedersen S. How to use a rotahaler. Arch Dis Child. 1986 Jan;61(1):11–14. doi: 10.1136/adc.61.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Richards R., Dickson C. R., Renwick A. G., Lewis R. A., Holgate S. T. Absorption and disposition kinetics of cromolyn sodium and the influence of inhalation technique. J Pharmacol Exp Ther. 1987 Jun;241(3):1028–1032. [PubMed] [Google Scholar]
- Richards R., Simpson S. F., Renwick A. G., Holgate S. T. Inhalation rate of sodium cromoglycate determines plasma pharmacokinetics and protection against AMP-induced bronchoconstriction in asthma. Eur Respir J. 1988 Dec;1(10):896–901. [PubMed] [Google Scholar]