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. Author manuscript; available in PMC: 2016 Nov 17.
Published in final edited form as: Circulation. 2015 Sep 10;132(20):1880–1890. doi: 10.1161/CIRCULATIONAHA.115.016160

Figure 6.

Figure 6

In vivo imaging of anti-IL-1β treatment effects on infarct protease activity and post-MI remodeling. (a) Evaluation of post-MI remodeling in ApoE−/− mice by cardiac MRI. Each panel shows the short axis of the mid left-ventricular segment at the end of diastole. Infarct size was measured as gadolinium enhanced hypokinetic area on day 1 after MI. (b) Imaging infarct protease activity 7d after MI in ApoE−/− mice by Fluorescence Molecular Tomography-Computed Tomography (FMT/CT) (n = 8 per group). (c) End-diastolic volumes (EDV) and left-ventricular ejection fraction (LV-EF) were examined serially on day 1 and 21 and are displayed as absolute values on day 21 (n = 6 per group, mean ± SD, *p<0.05, Mann-Whitney test).