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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Nanomedicine. 2015 Aug 15;11(8):1925–1938. doi: 10.1016/j.nano.2015.07.012

Figure 3. Secretion of IL-8 by human blood cells requires de novo synthesis of the protein but not mRNA.

Figure 3

Human whole blood was treated with the negative control (NC, cell culture medium), the positive control (PC, 20 ng/mL of the LPS), or test agents (Taxol®, Cremophor-EL, or Abraxane®) at equivalent paclitaxel concentration of 25 μM. The amounts of IL-8 mRNA (A) and IL-8 protein (B) were measured in the same specimens; each bar represents mean response and standard deviation from ten donors (N=10). The level of IL-8 protein in supernatants 2 h (C) and 20 h (D) after treatment with Cremophor 25 μM and the PC. Each bar shown the mean response (N=2, %CV < 20) for each of 3 tested individual donors.