Fig. 3.

Cortical bone phenotype of WT (solid) and Phospho1 KO (dashed) tibia at 5, 7, 16 and 34 weeks of age. Ex vivo high-resolution analyses of cortical bone at 37% of total tibial length showing (A) cortical total volume (TV), (B) cortical bone volume/total volume (BV/TV), (C) cortical cross sectional thickness, (D) cortical total porosity, (E) cortical degree of anisotropy, (F) cortical mean polar moment of inertia, (G) cortical tissue mineral density and (H) representative 3D μCT images of tibial cortical bone at 37% tibial length in WT and KO mice. Linear graphs represent means ± SEM. Group sizes were n = 6 for 5-, 7- and 16- as well as n = 5 for 34-week old WT and KO mice. Statistical comparisons: p < 0.05 WT and KO of same age.