Abstract
A classical function of C1q is to bind immune complexes and initiate complement activation producing membrane lytic complexes, opsonins and anaphylatoxins. This classical pathway of complement activation is also elicited when C1q binds some other ligands. Besides complement activation, C1q also regulates cell differentiation, adhesion, migration, activation and survival. C1q deficiency is associated with autoimmunity as well as increased susceptibility to infections. In this article, we discuss the basic properties of C1q, its expression, and classical and regulatory functions.
Keywords: C1q, macrophage, dendritic cell, apoptotic cell, autoimmunity
Glossary
- DC
dendritic cell
- SLE
systemic lupus erythematosus
- MBL
mannan-binding lectin
- AC
apoptotic cell
- CRP
C-reactive protein
- LPS
lipopolysaccharide
- APC
antigen-presenting cell
- CR
complement receptor