Figure 2. SOX9 suppresses cervical carcinoma tumorigenesis in vivo.

Tumor growth curves (left) and tumor formation (right) of the BALB/c nude mice are shown with SiHa-SOX9 cells (A), HeLa-shSOX9 cells (B) and with SiHa-GFP cells (A) and HeLa-shGFP cells (B) as controls. All of the groups were injected the same number of cells (1×10⁵ cells). The error bars indicate the mean tumor volume±SD for three independent experiments.*P < 0.05. SOX9 and Ki-67 were detected in SiHa (C) and HeLa (D) and in tumor xenografts by immunohistochemistry. Original magnifications, x400.